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具有不同核数的铁硫簇的蛋白质的结构和电化学。第二部分。[4Fe-4S]和[3Fe-4S]铁硫蛋白。

Structure and electrochemistry of proteins harboring iron-sulfur clusters of different nuclearities. Part II. [4Fe-4S] and [3Fe-4S] iron-sulfur proteins.

机构信息

Dipartimento di Biotecnologie, Chimica e Farmacia dell'Università di Siena, Via A. De Gasperi 2, 53100 Siena, Italy.

出版信息

J Struct Biol. 2018 Jun;202(3):250-263. doi: 10.1016/j.jsb.2018.01.010. Epub 2018 Feb 8.

DOI:10.1016/j.jsb.2018.01.010
PMID:29428558
Abstract

In the context of the plethora of proteins harboring iron-sulfur clusters we have already reviewed structure/electrochemistry of metalloproteins expressing single types of iron-sulfur clusters (namely: {Fe(Cys)}, {FeS}, {FeS(X)} (X = Asp, Arg, His), {FeS(His)}, {FeS}, {FeS} and {FeS(nonthiolate ligand)} cores) and their synthetic analogs. More recently we are focussing on structure/electrochemistry of metalloproteins harboring iron-sulfur centres of different nuclearities. Having started such a subject with proteins harboring [4Fe-4S] and [2Fe-2S] clusters, we now depict the state of art of proteins containing [4Fe-4S] and [3Fe-4S] clusters.

摘要

在富含铁硫簇的众多蛋白质中,我们已经综述了表达单一类型铁硫簇的金属蛋白的结构/电化学性质(即:{Fe(Cys)}、{FeS}、{FeS(X)}(X=Asp、Arg、His)、{FeS(His)}、{FeS}、{FeS}和{FeS(非硫醇配体)}核心)及其合成类似物。最近,我们专注于具有不同核数的铁硫中心的金属蛋白的结构/电化学。从研究含有[4Fe-4S]和[2Fe-2S]簇的蛋白质开始,我们现在描述了含有[4Fe-4S]和[3Fe-4S]簇的蛋白质的最新进展。

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