Dipartimento di Biotecnologie, Chimica e Farmacia dell'Università di Siena, Via A. De Gasperi 2, 53100 Siena, Italy.
J Struct Biol. 2018 Jun;202(3):264-274. doi: 10.1016/j.jsb.2018.03.008. Epub 2018 Mar 27.
A systematic rationalization of the hundreds of proteins harboring iron-sulfur clusters and able to exhibit the most diverse biological functions is missing. In this picture we have already reviewed structure/electrochemistry of metalloproteins expressing single types of iron-sulfur centres [namely, {Fe(Cys)}, {FeS}, {FeS(X)} (X = Asp, Arg, His), {FeS(His)}, {FeS}, {FeS} and {FeS(nonthiolate ligand)}] and their synthetic analogs. Recently we are focussing on structure/electrochemistry of metalloproteins containing iron-sulfur centres of different nuclearities. Having started such a subject with proteins harboring [4Fe-4S] and [2Fe-2S] (Zanello, 2017c) as well as [4Fe-4S] and [3Fe-4S] (Zanello, in press) clusters, we now provide the state of art of proteins harboring [4Fe-4S], [3Fe-4S] and [2Fe-2S] clusters, a subject that resulted strictly limited to enzymes active in the respiratory Complex II.
目前缺少对具有铁硫簇且能够表现出最具多样性生物功能的数百种蛋白质进行系统合理化的研究。在本文中，我们已经综述了表达单一类型铁硫中心的金属蛋白的结构/电化学性质[即，{Fe(Cys)}、{FeS}、{FeS(X)}（X=Asp、Arg、His）、{FeS(His)}、{FeS}、{FeS}和{FeS(非硫醇配体)}]及其合成类似物。最近，我们专注于具有不同核数铁硫中心的金属蛋白的结构/电化学性质。我们从含有[4Fe-4S]和[2Fe-2S]（Zanello，2017c）以及[4Fe-4S]和[3Fe-4S]（Zanello，即将出版）簇的蛋白质开始研究这一课题，现在提供了含有[4Fe-4S]、[3Fe-4S]和[2Fe-2S]簇的蛋白质的最新研究进展，这一课题仅限于在呼吸复合物 II 中具有活性的酶。
