Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome, Kita-ku, Sapporo 060-0812, Japan.
R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo 182-0002, Japan.
Eur J Pharm Biopharm. 2018 Jun;127:171-176. doi: 10.1016/j.ejpb.2018.02.013. Epub 2018 Feb 8.
Lutein is located in the macula lutea in the human eye. Since humans cannot synthesize lutein de novo, it must be digested as food. Some studies including our previous study showed very low absorption of lutein after oral administration. These studies also suggested that the absorption route of lutein from the small intestine involves not only the blood but also the lymph. The aim of this study was to clarify the transfer of lutein into lymph and the tissue distribution after oral administration of a solid dispersion (SD) and a self-microemulsifying drug delivery system (SMEDDS) for improvement of the absorption. We used thoracic lymph-cannulated rats. It was shown that the plasma concentrations of lutein in the SD and SMEDDS groups were increased compared with that in the powder group. The absorption of lutein after oral administration of each formulation was clearly evaluated by its cumulative amount in lymph. Our data clearly showed that lutein is transferred into the lymph stream from the small intestine.
叶黄素位于人眼的黄斑区。由于人体不能从头合成叶黄素，因此必须将其作为食物消化。一些研究，包括我们之前的研究表明，口服后叶黄素的吸收率非常低。这些研究还表明，叶黄素从小肠吸收的途径不仅涉及血液，还涉及淋巴。本研究旨在阐明口服固体分散体（SD）和自微乳药物递送系统（SMEDDS）改善吸收后叶黄素向淋巴转移和组织分布。我们使用了胸部淋巴结结扎的大鼠。结果表明，SD 和 SMEDDS 组的血浆中叶黄素浓度高于粉末组。通过其在淋巴中的累积量，可清楚地评估每种制剂口服后的叶黄素吸收情况。我们的数据清楚地表明，叶黄素从小肠转移到了淋巴液中。
