Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringa, Avenida Colombo, n. 5790, K68, S05, Maringa, Parana, 87020-900, Brazil.
AAPS PharmSciTech. 2022 May 9;23(5):134. doi: 10.1208/s12249-022-02291-z.
Nature has been used as therapeutic resources in the treatment of diseases for many years. However, some natural compounds have poor water solubility. Therefore, physicochemical strategies and technologies are necessary for development of systems for carrying these substances. The self-emulsifying drug delivery systems (SEDDS) have been used as carriers of hydrophobic compounds in order to increase the solubility and absorption, improving their bioavailability. SEDDS are constituted with a mixture of oils and surfactants which, when come into contact with an aqueous medium under mild agitation, can form emulsions. In the last years, a wide variety of self-emulsifying formulations containing bioactive compounds from natural origin has been developed. This review provides a comprehensive overview of the main excipients and natural bioactive compounds composing SEDDS. In addition, applications, new technologies and innovation are reviewed as well. Examples of self-emulsifying formulations administered in different sites are also considered for a better understanding of the use of this strategy to modify the delivery of compounds from natural origin.
多年来，大自然一直被用作治疗疾病的治疗资源。然而，一些天然化合物的水溶性很差。因此，需要物理化学策略和技术来开发携带这些物质的系统。自乳化药物递送系统 (SEDDS) 已被用作疏水化合物的载体，以提高溶解度和吸收度，从而提高其生物利用度。SEDDS 由油和表面活性剂的混合物组成，当在温和搅拌下与水相接触时，可以形成乳液。近年来，已经开发出多种含有天然来源生物活性化合物的自乳化制剂。本综述全面概述了组成 SEDDS 的主要赋形剂和天然生物活性化合物。此外，还综述了应用、新技术和创新。还考虑了在不同部位给药的自乳化制剂的实例，以便更好地了解使用这种策略来改变天然来源化合物的递送。
