Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Department of Emergency Medicine, Faculty of Medicine, Acıbadem University, Istanbul, Turkey.
Med Princ Pract. 2018;27(2):99-106. doi: 10.1159/000487552. Epub 2018 Feb 11.
Delayed healing and non-union of fractures have a significant effect upon patient morbidity. Studies have therefore largely concentrated on accelerating fracture healing. This study was intended to compare the effect of "mad honey" and propolis on fracture healing using radiological and histopathological analysis.
Femur fracture was surgically performed on 48 rats, followed by fixation. Animals were then divided into 8 groups: 2 control groups (15- and 30-day) and 6 treatment groups (15- and 30-day normal honey, 15- and 30-day "mad honey," and 15- and 30-day propolis). Rats were sacrificed at the end of these periods, and radiological and histological examinations were performed.
Radiological healing in the propolis group after 15-day therapy was statistically better than in the control (p = 0.004) and normal honey (p = 0.006) groups. After 30-day therapy, healing in the propolis group (p = 0.005) and grayanotoxin-containing "mad honey" group (p = 0.007) were significantly better than in the control group. Histologically, there was a statistically significant difference between the 15-day propolis group and the other groups (control, honey, mad honey: p = 0.003, p = 0.003, and p = 0.002, respectively). We also found a statistically significant difference when the 30-day propolis group (p = 0.005) and "mad honey" group (p = 0.007) were compared to the control group.
This study shows that grayanotoxin-containing "mad honey" and propolis can accelerate fracture healing.
骨折延迟愈合和不愈合会显著增加患者的发病率。因此，研究主要集中在加速骨折愈合上。本研究旨在通过影像学和组织病理学分析比较“马德拉蜂蜜”和蜂胶对骨折愈合的影响。
48 只大鼠行股骨骨折切开复位内固定术，动物分为 8 组：2 个对照组（15 天和 30 天）和 6 个治疗组（15 天和 30 天普通蜂蜜、15 天和 30 天“马德拉蜂蜜”、15 天和 30 天蜂胶）。在这些时期结束时处死大鼠，并进行影像学和组织学检查。
治疗 15 天后，蜂胶组的影像学愈合明显优于对照组（p = 0.004）和普通蜂蜜组（p = 0.006）。治疗 30 天后，蜂胶组（p = 0.005）和含格雷森毒素的“马德拉蜂蜜”组（p = 0.007）的愈合明显优于对照组。组织学上，15 天蜂胶组与其他组之间存在统计学差异（对照组、蜂蜜组、马德拉蜂蜜组：p = 0.003、p = 0.003 和 p = 0.002）。当比较 30 天蜂胶组（p = 0.005）和“马德拉蜂蜜”组（p = 0.007）与对照组时，也发现了统计学差异。
本研究表明，含格雷森毒素的“马德拉蜂蜜”和蜂胶可加速骨折愈合。
