系统蜂胶刺激扩张缝中的新骨形成：一项组织形态计量学研究。
Systemic propolis stimulates new bone formation at the expanded suture: a histomorphometric study.
机构信息
Department of Orthodontics, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey.
出版信息
Angle Orthod. 2013 Mar;83(2):286-91. doi: 10.2319/032612-253.1. Epub 2012 Aug 20.
Abstract
OBJECTIVE
To investigate the effects of systemically given propolis on the expanded premaxillary suture in a rat study model.
MATERIALS AND METHODS
The 24 rats were randomly divided into three groups-only expansion (OE), expansion plus propolis (PRO), and nonexpansion (control) groups. After the 5-day expansion period was completed, the OE and PRO groups underwent 12 days of mechanical retention. At the end of this period, the animals were euthanatized and their pre-maxillae were dissected and fixed. Histomorphometric examination was performed to determine the number of osteoclasts, osteoblasts, and capillaries as well as the intensity of inflammatory cells and amount of new bone formation.
RESULTS
Statistical analysis showed that the intensities of inflammatory cells, number of osteoblasts, and amount of new bone formation were greater in the PRO group than in the other groups. The PRO group also had more osteoclasts and new capillaries.
CONCLUSION
Systemic use of propolis may hasten new bone formation at the expanded suture in rats.
摘要
目的
在大鼠实验模型中研究全身给予蜂胶对扩大的上颌前缝的影响。
材料和方法
24 只大鼠随机分为三组：仅扩张组（OE）、扩张加蜂胶组（PRO）和非扩张组（对照组）。扩张期结束后的 5 天，OE 和 PRO 组进行了 12 天的机械保留。在此期间结束时，处死动物并解剖和固定其上颌前。进行组织形态计量学检查以确定破骨细胞、成骨细胞和毛细血管的数量以及炎症细胞的强度和新骨形成的量。
结果
统计分析表明，PRO 组的炎症细胞强度、成骨细胞数量和新骨形成量均大于其他组。PRO 组还具有更多的破骨细胞和新毛细血管。
结论
全身使用蜂胶可能会加速大鼠扩张缝中的新骨形成。
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