Departments of Pediatrics,Emory University School of Medicine,Atlanta,GA,USA.
Pathology and Laboratory Medicine,Emory University School of Medicine,Atlanta,GA,USA.
Epidemiol Infect. 2018 Mar;146(4):465-467. doi: 10.1017/S0950268818000183. Epub 2018 Feb 12.
We compared rotavirus detection patterns before (2001-2006) and after (2008-2015) rotavirus vaccine introduction. We also compared rotavirus detection patterns in odd (2009, 2011, 2013, 2015) and even (2008, 2010, 2012, 2014) years post-vaccine separately. Results of stool rotavirus antigen testing from inpatient, outpatient and emergency department encounters from July 2000 to July 2015 at two paediatric hospital laboratories in Atlanta, Georgia were reviewed. Post-vaccine, rotavirus detection declined (30.2% vs. 13.7% (overall 54.6% decline, P <0.001)), occurred more frequently outside the rotavirus season (19.8% vs. 3.5%; P < 0.001), and was more common among older children (26 vs. 13 median months of age; P < 0.001). During odd years post-vaccine, rotavirus detection was significantly higher than even years (20.2% vs. 6.4%; P < 0.001). Rotavirus detection declined substantially and developed a biennial pattern in the post-vaccine era. The intensity and temporality of rotavirus detection in odd years post-vaccine resembled that observed pre-vaccine, although considerably reduced in magnitude.
我们比较了疫苗引入前后（2001-2006 年和 2008-2015 年）轮状病毒的检测模式。我们还分别比较了疫苗接种后奇数（2009、2011、2013、2015 年）和偶数（2008、2010、2012、2014 年）年份的轮状病毒检测模式。回顾了 2000 年 7 月至 2015 年 7 月佐治亚州亚特兰大市两家儿科医院实验室住院、门诊和急诊患者粪便轮状病毒抗原检测结果。疫苗接种后，轮状病毒的检测率下降（30.2% vs. 13.7%（总体下降 54.6%，P <0.001）），更多地发生在轮状病毒季节之外（19.8% vs. 3.5%；P <0.001），且更多见于年龄较大的儿童（26 个月 vs. 13 个月中位年龄；P <0.001）。疫苗接种后奇数年份，轮状病毒的检测率明显高于偶数年份（20.2% vs. 6.4%；P <0.001）。疫苗接种后，轮状病毒的检测率大幅下降，并呈现出两年一次的模式。疫苗接种后奇数年份轮状病毒检测的强度和时间性与疫苗接种前相似，尽管幅度明显降低。
