Norman R A, Dzielak D J
Proc Soc Exp Biol Med. 1986 Sep;182(4):448-53. doi: 10.3181/00379727-182-42364.
Overactivity of the sympathetic nervous system and immunologic dysfunction have been shown to contribute to development and maintenance of hypertension in the Okamoto spontaneously hypertensive rat (SHR). In this study, the combined effects of reduction in sympathetic activity and immunologic manipulation on spontaneous hypertension have been determined. Neonatal SHRs received sham implants or implants of thymic tissue from Wistar donor rats. In addition, the thymus-implanted SHRs underwent bilateral renal denervation when they were 6 weeks old. At the same time, the sham-implanted SHRs underwent sham renal denervation. The denervations or sham operations were repeated when the SHRs were 9, 12, 15, and 18 weeks old. Wistar-Kyoto (WKY) rats also underwent serial sham renal denervations. Tail-cuff pressure measurements indicated that approximately 75% of the chronic hypertension in the SHRs was prevented by the combination of thymic implants and renal denervations. Direct arterial pressure measurements confirmed these results; when the rats were 21 weeks old, mean arterial pressure averaged 177 +/- 5.5 mm Hg in sham-operated SHRs, 134 +/- 2.7 mm Hg in implanted, denervated SHRs, and 121 +/- 2.1 mm Hg in sham-operated WKY rats. These data indicate that overactivity of the sympathetic nervous system and immunologic dysfunction account for the majority of the hypertension in the Okamoto SHR.
交感神经系统功能亢进和免疫功能紊乱已被证明与冈本自发性高血压大鼠（SHR）高血压的发生和维持有关。在本研究中，已确定降低交感神经活动和免疫干预对自发性高血压的联合作用。新生SHR接受假植入或植入来自Wistar供体大鼠的胸腺组织。此外，胸腺植入的SHR在6周龄时接受双侧肾去神经支配。同时，假植入的SHR接受假肾去神经支配。当SHR分别为9、12、15和18周龄时，重复去神经支配或假手术。Wistar-Kyoto（WKY）大鼠也接受了系列假肾去神经支配。尾袖法测量血压表明，胸腺植入和肾去神经支配相结合可预防约75%的SHR慢性高血压。直接动脉压测量证实了这些结果；当大鼠21周龄时，假手术的SHR平均动脉压为177±5.5 mmHg，植入并去神经支配的SHR为134±2.7 mmHg，假手术WKY大鼠为121±2.1 mmHg。这些数据表明，交感神经系统功能亢进和免疫功能紊乱是冈本SHR高血压的主要原因。
