Laboratory of Vascular Homeostasis Regulation, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Korea.
BMB Rep. 2018 Apr;51(4):174-181. doi: 10.5483/bmbrep.2018.51.4.033.
A number of genes have been therapeutically targeted to relieve cancer, but cancer relapse is still a growing issue. The concept that the surrounding tumor environment is critical for the progression of cancer may foster an answer to the issue of cancer malignancy. Runt domain transcription factors (RUNX1, 2, and 3) are evolutionarily conserved and have been intensively studied for their roles in normal development and pathological conditions. During tumor growth, a hypoxic microenvironment and infiltration of the tumor by immune cells are common phenomena. In this review, we briefly introduce the consequences of hypoxia and immune cell infiltration into the tumor microenvironment with a focus on RUNX3 as a critical regulator. Furthermore, based on our current knowledge of the functional role of RUNX3 in hypoxia and immune cell maintenance, a probable therapeutic intervention is suggested for the effective management of tumor growth and malignancy. [BMB Reports 2018; 51(4): 174-181].
许多基因已被作为治疗靶点用于缓解癌症，但癌症复发仍然是一个日益严重的问题。肿瘤周围环境对于癌症进展至关重要的观点可能为癌症恶性程度的问题提供答案。 runt 结构域转录因子（RUNX1、2 和 3）在进化上是保守的，并且已经对其在正常发育和病理条件下的作用进行了深入研究。在肿瘤生长过程中，缺氧微环境和肿瘤浸润免疫细胞是常见现象。在这篇综述中，我们简要介绍了缺氧和免疫细胞浸润对肿瘤微环境的影响，重点介绍了 RUNX3 作为关键调节因子的作用。此外，基于我们目前对 RUNX3 在缺氧和免疫细胞维持中的功能作用的了解，提出了一种可能的治疗干预措施，以有效控制肿瘤生长和恶性程度。[BMB 报告 2018；51(4): 174-181]。
