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巴巴苏油微乳液作为一种天然产品用于改善人体免疫系统功能。

Microemulsion of babassu oil as a natural product to improve human immune system function.

作者信息

Pessoa Rafael Souza, França Eduardo Luzia, Ribeiro Elton Brito, Lanes Patrícia Kelly Dias, Chaud Natalina Galdeano Abud, Moraes Lucélia Campelo Albuquerque, Honorio-França Adenilda Cristina

机构信息

Post Graduate Program in Material Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.

Post Graduate Program in Material Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil ; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.

出版信息

Drug Des Devel Ther. 2014 Dec 16;9:21-31. doi: 10.2147/DDDT.S73756. eCollection 2015.

DOI:10.2147/DDDT.S73756
PMID:25565770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4274040/
Abstract

BACKGROUND

The aim of this study was to develop and characterize a babassu oil microemulsion system and determine the effect of this microemulsion on the functional activity of phagocytes.

METHODS

The microemulsion was formulated using distilled water, babassu as the oil phase component, Sorbitan monooleate-Span 80(®) (SP), Polysorbate 80-Tween 80(®) (TW), and 1-butanol (BT). Pseudoternary diagrams were prepared, and microemulsion diagram regions were preselected. Rheological characterization and preliminary and accelerated stability tests were performed. The effect of the microemulsion on the interactions between leukocytes and bacteria was determined by superoxide release, phagocytosis, and microbicidal activity.

RESULTS

The developed formulation SP/TW/BT (4.2/4.8/1.0) was classified as oil/water, showed a Newtonian profile, and had linear viscosity. When we assessed the interaction of the microemulsion or babassu oil with phagocytes, we observed an increase in superoxide, phagocytosis, and microbicidal activity.

CONCLUSION

The babassu oil microemulsion system is an option for future applications, including for vaccine delivery systems. Babassu oil is a natural product, so is an alternative for future immunotherapy strategies, in particular for infectious diseases.

摘要

背景

本研究的目的是开发并表征一种巴巴苏油微乳体系，并确定该微乳对吞噬细胞功能活性的影响。

方法

使用蒸馏水、巴巴苏油作为油相成分、脱水山梨醇单油酸酯 - 司盘80（®）（SP）、聚山梨醇酯80 - 吐温80（®）（TW）和正丁醇（BT）配制微乳。绘制伪三元相图，并预选微乳相图区域。进行流变学表征以及初步和加速稳定性试验。通过超氧化物释放、吞噬作用和杀菌活性来确定微乳对白细胞与细菌之间相互作用的影响。

结果

所开发的配方SP/TW/BT（4.2/4.8/1.0）被归类为油包水型，呈现牛顿流体特性，且具有线性粘度。当评估微乳或巴巴苏油与吞噬细胞的相互作用时，我们观察到超氧化物、吞噬作用和杀菌活性均有所增加。

结论

巴巴苏油微乳体系是未来应用的一个选择，包括用于疫苗递送系统。巴巴苏油是一种天然产物，因此是未来免疫治疗策略的一种替代物，特别是对于传染病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/ffc14c2b94b2/dddt-9-021Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/ef83cf318cab/dddt-9-021Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/8170adfc6697/dddt-9-021Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/b82b42a441a0/dddt-9-021Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/9cd0e11d65c6/dddt-9-021Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/0bde95f4fbe9/dddt-9-021Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/0078aeb75f1b/dddt-9-021Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/ffc14c2b94b2/dddt-9-021Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/ef83cf318cab/dddt-9-021Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/8170adfc6697/dddt-9-021Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/b82b42a441a0/dddt-9-021Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/9cd0e11d65c6/dddt-9-021Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/0bde95f4fbe9/dddt-9-021Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/0078aeb75f1b/dddt-9-021Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad27/4274040/ffc14c2b94b2/dddt-9-021Fig7.jpg

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2
Nutraceuticals safety and efficacy in migraine without aura in a population of children affected by neurofibromatosis type I.神经纤维瘤病 I 型患儿偏头痛无先兆人群中营养保健品的安全性和疗效。
Neurol Sci. 2013 Nov;34(11):1905-9. doi: 10.1007/s10072-013-1403-z. Epub 2013 Mar 27.
3
Brazilian propolis: a natural product that improved the fungicidal activity by blood phagocytes.
改良褪黑素释放对人初乳中性粒细胞诱导MCF-7细胞系死亡的影响。
Int J Cell Biol. 2022 May 18;2022:8069188. doi: 10.1155/2022/8069188. eCollection 2022.
4
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Evid Based Complement Alternat Med. 2020 Sep 24;2020:8858291. doi: 10.1155/2020/8858291. eCollection 2020.
5
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6
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7
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