López-Martínez Cecilia, Huidobro Covadonga, Albaiceta Guillermo M, López-Alonso Inés
Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain.
Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.
Ann Transl Med. 2018 Jan;6(2):28. doi: 10.21037/atm.2017.12.08.
Cell migration is a core process to preserve homeostasis. Release of chemotactic signals induces changes in cell cytoskeleton to facilitate migration. This includes the rearrangement of cytoskeleton, genomic reprogramming and the modification of the surrounding extracellular matrix (ECM) to allow the motion of cells through. In the special case of repair after acute lung injury, cells must migrate while exposed to an increased mechanical stretch caused either by an increased work of breathing or positive-pressure ventilation. Interestingly, the cell response to this increased mechanical load can modify virtually all the mechanisms involved in cell migration. In this review we explore the interplay between stretch and the machinery responsible for cell migration. A translational approach to find new therapies in acute lung injury must take into account these interactions in order to develop effective treatments that promote lung repair.
细胞迁移是维持体内平衡的核心过程。趋化信号的释放会诱导细胞细胞骨架发生变化以促进迁移。这包括细胞骨架的重排、基因组重编程以及对周围细胞外基质（ECM）的修饰，以使细胞能够通过。在急性肺损伤后的修复这种特殊情况下，细胞在暴露于因呼吸功增加或正压通气导致的机械牵张增加时必须迁移。有趣的是，细胞对这种增加的机械负荷的反应实际上可以改变参与细胞迁移的所有机制。在本综述中，我们探讨牵张与负责细胞迁移的机制之间的相互作用。在急性肺损伤中寻找新疗法的转化方法必须考虑这些相互作用，以便开发促进肺修复的有效治疗方法。
