Kalvaria I, Rabinowitz S, Frith L O, Kirsch R E
Thromb Res. 1986 Aug 1;43(3):287-91. doi: 10.1016/0049-3848(86)90148-9.
The terminal fibrinogen degradation product fragment D1 is known to regulate fibrinogen synthesis but the determinants in the D1 molecule responsible for this property are not known. The effect of fragment D1 on fibrinogen synthesis by the isolated perfused rat liver was studied using the (14C) carbonate method. Addition of 25 mg of fragment D1 to 100 ml of whole blood perfusate resulted in a significant increase in fibrinogen synthesis. When the C-terminal end of the gamma-chain of D1 was further plasmin-degraded to form fragment D3 this fibrinogen-enhancing effect was lost. Our studies suggest that the C-terminal of the gamma-chain of fragment D1 plays a role in regulating fibrinogen synthesis by the isolated rat liver.
已知终末纤维蛋白原降解产物片段D1可调节纤维蛋白原的合成，但负责此特性的D1分子中的决定因素尚不清楚。使用（14C）碳酸盐法研究了片段D1对离体灌注大鼠肝脏纤维蛋白原合成的影响。向100ml全血灌注液中添加25mg片段D1导致纤维蛋白原合成显著增加。当D1的γ链C末端进一步被纤溶酶降解形成片段D3时，这种纤维蛋白原增强作用丧失。我们的研究表明，片段D1的γ链C末端在调节离体大鼠肝脏纤维蛋白原合成中起作用。
