Division of Endocrinology and Metabolism and Diabetes Center, 1st Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 55535 Thessaloniki, Greece.
Brain and Neurodegenerative Disorders Research Laboratories, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34381, Turkey.
Nutrients. 2021 Dec 26;14(1):90. doi: 10.3390/nu14010090.
Dyshomeostasis of vitamin D-binding protein (VDBP) has been implicated in the pathogenesis of various pregnancy complications, including preeclampsia, preterm birth, gestational diabetes, and adverse metabolic profiles in the offspring. VDBP polymorphisms have been consistently reported to contribute to this intriguing interplay. Until recently, the effects of VDBP polymorphism heterogeneity on maternal and neonatal adipomyokine profiles have not been investigated, specifically after incorporating the different maternal and neonatal 25-hydroxyvitamin D concentration cut-offs at birth. We aimed to investigate the potential effects of maternal and neonatal VDBP polymorphisms on adiponectin, irisin, and VDBP concentrations at birth, according to different cut-offs of vitamin D status, in maternal-neonatal dyads recruited from the sunny region of Northern Greece. We obtained blood samples from 66 mother-child pairs at birth. Results indicated that (i) Neonatal serum biomarkers were not affected by any included neonatal VDBP polymorphism according to different cut-offs of neonatal vitamin D status at birth, (ii) neonatal VDBP concentration was elevated in neonates with maternal rs7041 GG genotype, (iii) maternal 25(OH)D at ≤75 nmol/L resulted in increased concentrations of maternal VBDP and irisin concentrations in women with CC genotype for rs2298850 and rs4588,whereas this effect was also evident for this cut-off for neonatal VDBP concentrations at birth for GC genotype for rs 7041, and (iv) no significant effect of neonatal VDBP polymorphisms was observed on neonatal VDBP, adiponectin, or irisin levels when stratified according to maternal 25(OH)D cut-offs. In conclusion, these findings confirm that among women with the combination of CC genotype for rs2298850 and rs4588, a specific high cut-off of maternal 25(OH)D results in increasing maternal VBDP concentrations, hence providing a mechanistic rationale for aiming for specific cut-offs of vitamin D after supplementation during pregnancy, in daily clinical practice.
维生素 D 结合蛋白（VDBP）的平衡失调与各种妊娠并发症的发病机制有关，包括子痫前期、早产、妊娠期糖尿病和后代不良的代谢特征。VDBP 多态性一直被认为与这种有趣的相互作用有关。直到最近，VDBP 多态性异质性对母代和新生儿脂肪细胞-肌细胞因子谱的影响尚未被研究，特别是在纳入出生时不同的母代和新生儿 25-羟维生素 D 浓度截止值之后。我们旨在根据希腊北部阳光充足地区招募的母婴对子中不同的维生素 D 状态截止值，研究母代和新生儿 VDBP 多态性对出生时脂联素、鸢尾素和 VDBP 浓度的潜在影响。我们从 66 对母婴中获得了出生时的血液样本。结果表明：（i）根据出生时新生儿维生素 D 状态的不同截止值，新生儿血清生物标志物不受任何纳入的新生儿 VDBP 多态性的影响；（ii）母代 rs7041 GG 基因型的新生儿血清 VDBP 浓度升高；（iii）母代 25(OH)D 浓度≤75nmol/L 导致 CC 基因型女性的母代 VBDP 和鸢尾素浓度升高rs2298850 和 rs4588，而这一效应在出生时新生儿 VDBP 浓度的这一截止值对于 rs7041 的 GC 基因型也是明显的；（iv）根据母代 25(OH)D 截止值分层，新生儿 VDBP 多态性对新生儿 VDBP、脂联素或鸢尾素水平无显著影响。总之，这些发现证实，在 rs2298850 和 rs4588 均为 CC 基因型的女性中，母代 25(OH)D 的特定高截止值导致母代 VBDP 浓度升高，从而为在日常临床实践中补充维生素 D 后针对特定的维生素 D 截止值提供了一种机制上的合理依据。
