Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Faculty of Medicine, University of Oslo, Norway; Section of Cardiovascular and Renal Research, Oslo University Hospital Ulleval, Norway.
Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Faculty of Medicine, University of Oslo, Norway.
Cytokine. 2018 May;105:17-22. doi: 10.1016/j.cyto.2018.02.006. Epub 2018 Feb 9.
Coronary artery disease (CAD) is considered a low-grade inflammatory disease. We aimed to identify effects of short-term strenuous exercise on mediators of systemic inflammation, endothelial and platelet activation in patients with angiographically verified CAD. We hypothesized that a more pronounced inflammatory response would be present in patients with CAD than in those without CAD.
In subjects with symptoms indicative of stable CAD, an exercise stress test on a bicycle ergometer was performed. Venous blood samples, taken at rest and within 5 min after end of exercise, were analyzed for the following markers by ELISAs: TNF-α, IL-6, MCP-1, ICAM-1, VCAM-1, E-selectin, P-selectin, CD40L and RANTES. All participants underwent conventional coronary angiography. CAD was defined as having any degree of atherosclerosis.
A total of 110 patients were included, of whom 74 were found to have CAD. Mean exercise duration was 10:06 ± 3:56 min with no significant difference between the two groups. All measured markers changed significantly during exercise (p ≤ 0.012). A significantly less pronounced increase in CD40L in the CAD group than in the no CAD group was observed (p = 0.050), however, after adjustment for hematocrit this difference was no longer significant.
An instant inflammatory response was observed during short-term strenuous exercise in patients with symptoms of CAD. However, the exercise mediated response was not more pronounced in patients with CAD.
冠心病（CAD）被认为是一种低度炎症性疾病。我们旨在确定短期剧烈运动对有血管造影证实的 CAD 患者全身炎症介质、内皮和血小板激活的影响。我们假设 CAD 患者的炎症反应会比没有 CAD 的患者更明显。
在有稳定 CAD 症状的患者中，进行自行车测力计运动应激试验。在休息时和运动结束后 5 分钟内采集静脉血样，通过 ELISA 分析以下标志物：TNF-α、IL-6、MCP-1、ICAM-1、VCAM-1、E-选择素、P-选择素、CD40L 和 RANTES。所有参与者均接受常规冠状动脉造影。CAD 定义为有任何程度的动脉粥样硬化。
共纳入 110 例患者，其中 74 例被诊断为 CAD。平均运动时间为 10:06±3:56 分钟，两组间无显著差异。所有测量的标志物在运动过程中均发生显著变化（p≤0.012）。在 CAD 组中，CD40L 的增加明显低于无 CAD 组（p=0.050），然而，在校正红细胞压积后，这种差异不再显著。
在有 CAD 症状的患者中，短期剧烈运动可引起即刻炎症反应。然而，CAD 患者的运动介导反应并不更明显。
