日本脑炎病毒诱导的抑制性T细胞及其迟发型超敏反应产物的特性研究

Characterization of Japanese éncephalitis virus-induced suppressor T cells and their products for delayed type hypersensitivity.

作者信息

Rawat S, Mathur A, Chaturvedi U C

出版信息

Br J Exp Pathol. 1986 Aug;67(4):571-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2013045/

Abstract

Intraperitoneal inoculation with Japanese encephalitis virus (JEV) induces the generation of T suppressor cells for delayed type hypersensitivity (Ts-DTH) in Swiss albino mice. The Ts-DTH are hydrocortisone resistant, partially sensitive to X-irradiation and the membrane phenotype of Ts cells is Ly I+. Ts-DTH suppression is mediated through the production of soluble suppressor factor (SF-DTH). SF-DTH is non-dialysable but passes through 450 nm filter and does not sediment after centrifugation at 100,000 g for 2 h; chromatography on Sephadex G-100 indicates an approximate molecular weight of 12,000.

摘要

在瑞士白化小鼠中，腹腔接种日本脑炎病毒（JEV）可诱导产生用于迟发型超敏反应的抑制性T细胞（Ts-DTH）。Ts-DTH对氢化可的松有抗性，对X射线部分敏感，Ts细胞的膜表型为Ly I+。Ts-DTH抑制是通过可溶性抑制因子（SF-DTH）的产生介导的。SF-DTH不可透析，但可通过450nm滤膜，在100,000g离心2小时后不沉淀；在Sephadex G-100上进行色谱分析表明其近似分子量为12,000。

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引用本文的文献

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本文引用的文献

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Clones of helper T cells mediate antigen-specific, H-2-restricted DTH.

Nature. 1981 Mar 5;290(5801):62-3. doi: 10.1038/290062a0.

2

Characterization of two different Ly-1+ T cell populations that mediate delayed-type hypersensitivity.介导迟发型超敏反应的两种不同Ly-1⁺ T细胞群体的特征分析。

J Immunol. 1984 Nov;133(5):2402-11.

3

Induction and Ly phenotype of suppressor T cells in mice during primary infection with dengue virus.登革病毒初次感染小鼠期间抑制性T细胞的诱导及Ly表型

Immunology. 1984 Jan;51(1):51-6.

4

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Immunology. 1984 Jul;52(3):395-402.

5

Delayed-type hypersensitivity to influenza virus. Induction of antigen-specific suppressor T cells for delayed-type hypersensitivity to hemagglutinin during influenza virus infection in mice.对流感病毒的迟发型超敏反应。在小鼠流感病毒感染期间诱导针对血凝素迟发型超敏反应的抗原特异性抑制性T细胞。

J Exp Med. 1980 Apr 1;151(4):799-814. doi: 10.1084/jem.151.4.799.

6

Estimation of the molecular weights of proteins by Sephadex gel-filtration.用葡聚糖凝胶过滤法估算蛋白质的分子量

Biochem J. 1964 May;91(2):222-33. doi: 10.1042/bj0910222.

7

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J Exp Med. 1974 Jan 1;139(1):13-23. doi: 10.1084/jem.139.1.13.

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