Kapp J A, Pierce C W, Theze J, Benacerraf B
Fed Proc. 1978 Aug;37(10):2361-64.
The activity of suppressor T cells has been demonstrated in almost every phase of the immune response. These regulatory cells modulate both humoral and cell-mediated immunity utilizing antigen-specific and nonspecific mechanisms. For comparative purposes two murine models are described, the nonspecific suppressor T cell stimulated by the mitogen concanavalin A and the antigen-specific suppressor T cell stimulated by injection of the synthetic terpolymer acid 60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice. These two T cells are similar to expression of Ly alloantigens, ability to inhibit antibody responses, and the mediation of suppression, at least in part, by soluble products. However, differences in radio-resistance and antigenic specificity of the suppressor T cells, as well as differences in molecular characteristics of the soluble factors and their targets suggest that these T cells regulate the immune response by different mechanisms. The relationship of these two suppressor T cells to other nonspecific and antigen-specific suppressor T cells is discussed.
抑制性T细胞的活性几乎在免疫反应的每个阶段都得到了证实。这些调节性细胞利用抗原特异性和非特异性机制调节体液免疫和细胞介导的免疫。为了进行比较，描述了两种小鼠模型：由促有丝分裂剂刀豆球蛋白A刺激的非特异性抑制性T细胞，以及通过向无反应小鼠注射合成三元共聚物酸60-L-丙氨酸30-L-酪氨酸10（GAT）刺激的抗原特异性抑制性T细胞。这两种T细胞在Ly同种异体抗原的表达、抑制抗体反应的能力以及至少部分通过可溶性产物介导抑制方面相似。然而，抑制性T细胞在放射抗性和抗原特异性方面的差异，以及可溶性因子及其靶标的分子特征差异表明，这些T细胞通过不同机制调节免疫反应。讨论了这两种抑制性T细胞与其他非特异性和抗原特异性抑制性T细胞的关系。
