Research Center in Biological Sciences (NUPEB), Federal University of Ouro Preto, Ouro Preto, MG, Brazil; School of Nutrition, Federal University of Ouro Preto, Ouro Preto, MG, Brazil.
Research Center in Biological Sciences (NUPEB), Federal University of Ouro Preto, Ouro Preto, MG, Brazil; School of Nutrition, Federal University of Ouro Preto, Ouro Preto, MG, Brazil.
Food Res Int. 2018 Mar;105:563-569. doi: 10.1016/j.foodres.2017.11.067. Epub 2017 Nov 29.
The ability of foods to aid in the prevention of chronic metabolic diseases, has recently become an area of increased interest. In addition, there is growing interest in exploring the benefits of consuming underutilized fruits as alternatives to commercially available fruits. Eugenia uvalha Cambess (uvaia) is a native fruit of Brazil with great market and phytotherapy potential. The present study was conducted to investigate the effects of uvaia juice (UJ) on the levels of protein carbonyls (PCO) and antioxidant enzymes in the livers of rats fed a high-fat diet.
Thirty-two female rats were randomly assigned to four groups. The rats were fed either a standard diet (group C) or a high-fat diet (group HF). In addition, groups CUJ and HFUJ were treated with UJ (2mL/day) administered via gavage for 8weeks.
In our study, UJ displayed high antioxidant activity (135.14±9.74 GAE/100g). Administration of UJ caused a significantly reduced concentration of rat liver PCO (47.4%), which was associated with a 29% increase in catalase activity. A significant increase in the concentration of oxidized glutathione (GSSG) (15.04±5.08nmol/ml) and a reduction in the reduced glutathione/oxidized glutathione ratio (GSH/GSSG) (11.30±2.68) were found in the HF group, whilst these changes were not observed in the HFUJ group (a result similar to that of group C).
Our results demonstrate that UJ decreases oxidative damage by improving antioxidant efficiency and attenuating oxidative damage to proteins.
食物在预防慢性代谢性疾病方面的作用，最近成为一个研究热点。此外，人们越来越关注探索食用未充分利用的水果作为商业水果替代品的益处。Eugenia uvalha Cambess（uvaia）是一种原产于巴西的水果，具有巨大的市场和植物疗法潜力。本研究旨在探讨 uvaia 果汁（UJ）对高脂肪饮食喂养大鼠肝脏蛋白羰基（PCO）和抗氧化酶水平的影响。
将 32 只雌性大鼠随机分为四组。大鼠分别喂食标准饮食（C 组）或高脂肪饮食（HF 组）。此外，CUJ 和 HFUJ 组通过灌胃给予 UJ（每天 2mL）治疗 8 周。
在我们的研究中，UJ 表现出较高的抗氧化活性（135.14±9.74 GAE/100g）。UJ 给药导致大鼠肝脏 PCO 浓度显著降低（47.4%），同时过氧化氢酶活性增加 29%。HF 组中氧化型谷胱甘肽（GSSG）浓度显著增加（15.04±5.08nmol/ml），还原型谷胱甘肽/氧化型谷胱甘肽比值（GSH/GSSG）降低（11.30±2.68），而 HFUJ 组未观察到这些变化（与 C 组相似）。
我们的结果表明，UJ 通过提高抗氧化效率和减轻蛋白质氧化损伤来减少氧化损伤。
