Cancer Registry of Rhineland-Palatinate, Große Bleiche 46, 55116, Mainz, Germany.
Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg University Mainz, 55101, Mainz, Germany.
BMC Public Health. 2018 Feb 12;18(1):235. doi: 10.1186/s12889-018-5131-4.
The population-based incidence of sarcoma and its histological subtypes in Germany is unknown. Up-to-date information on a disease with an incidence comparable to other cancer entities is of high public health relevance. The aim of this study was to determine this incidence and to detect significant changes in incidence trends using data from German epidemiological cancer registries.
Pooled data from the German Centre for Cancer Registry Data with a primary diagnosis occurring in 2013 were used. To date, this is the latest data on cancer incidence available for Germany. All German cancer registries with sufficient completeness were included (10 out of 11), covering a population of 70.0 million people, representing 87% of the German population. All malignant sarcomas according to the RARECARE Project and the WHO classification 2002 were considered for analysis and, above all, gastrointestinal stromal tumours (GIST) of uncertain behaviour. Sensitivity analysis was performed excluding certain histologies.
The analysis included 3404 cases in men and 3442 cases in women diagnosed in 2013. The age adjusted sarcoma incidence (European standard) was 7.4 (men) and 6.6 (women) per 100,000 inhabitants. About 70% of sarcomas were soft tissue sarcomas, about 22% GIST, and about 9% bone sarcomas. The most common histological subtypes besides GIST were fibrosarcomas (14%) and liposarcomas (12%) in men and complex mixed and stromal neoplasms (22%), non-uterine leiomysarcomas (10%) and fibrosarcomas (9%) in women. Considering the trend for the years of diagnosis 2004 to 2013, there was a significant increase in incidence for GIST while the incidence of soft tissue sarcomas (only men) as well as of bone sarcoma stayed constant over time. As to soft tissue sarcoma in women, the incidence stayed constant up to the year 2009 and significantly decreased afterwards.
This study is the first detailed analysis of a German-wide population-based sarcoma incidence showing results comparable to the incidence detected in the RARECARE Project.
德国人群中肉瘤及其组织学亚型的发病率尚不清楚。对于一种发病率与其他癌症实体相当的疾病，提供最新信息具有重要的公共卫生意义。本研究旨在利用德国流行病学癌症登记处的数据确定这种发病率，并检测发病率趋势的显著变化。
使用德国癌症登记数据中心的汇总数据，这些数据的主要诊断发生在 2013 年。到目前为止，这是德国最新的癌症发病率数据。所有符合要求的德国癌症登记处（11 个中的 10 个）都包括在内，覆盖了 7000 万人口，占德国人口的 87%。根据 RARECARE 项目和 2002 年世界卫生组织分类，对所有恶性肉瘤进行了分析，特别是行为不确定的胃肠道间质瘤（GIST）。进行了敏感性分析，排除了某些组织学。
分析包括 2013 年诊断的 3404 例男性和 3442 例女性病例。年龄调整后的肉瘤发病率（欧洲标准）为男性 7.4（每 10 万人）和女性 6.6（每 10 万人）。大约 70%的肉瘤为软组织肉瘤，约 22%为 GIST，约 9%为骨肉瘤。除 GIST 外，最常见的组织学亚型为男性纤维肉瘤（14%）和脂肪肉瘤（12%），女性为复杂混合性和基质性肿瘤（22%）、非子宫平滑肌肉瘤（10%）和纤维肉瘤（9%）。考虑到 2004 年至 2013 年的诊断年份趋势，GIST 的发病率显著增加，而软组织肉瘤（仅男性）和骨肉瘤的发病率随时间保持不变。至于女性的软组织肉瘤，发病率在 2009 年之前保持不变，之后显著下降。
这是第一项关于德国全人群肉瘤发病率的详细分析，结果与 RARECARE 项目检测到的发病率相当。
