抗 PD-1 治疗联合立体定向放射外科治疗脑转移胃癌患者：病例报告。
Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report.
机构信息
Departments of Internal Medicine, Chonnam National University Medical School, Gwangju, 501-757, South Korea.
Departments of Pathology, Chonnam National University Medical School, Gwangju, 501-757, South Korea.
出版信息
BMC Cancer. 2018 Feb 12;18(1):173. doi: 10.1186/s12885-017-3906-0.
BACKGROUND
Brain metastases from gastric cancer are difficult to treat and their prognosis is poor. Despite various possible treatments, the survival rate of such patients is still unsatisfactory; therefore, new treatment modalities or combinations of therapies need to be explored.
CASE PRESENTATION
We herein discuss a case of a 38-year-old man initially diagnosed with a gastric cancer brain metastasis. At first, only stereotactic radiosurgery (SRS) was performed, but it was not effective. After the brain and systemic metastases progressed, SRS and anti-PD-1 therapy were administered in combination, and the brain and intra-abdominal metastatic lesions responded satisfactorily.
CONCLUSION
The combination of anti-PD-1 therapy and SRS could be effective against gastric cancer with brain metastases.
背景
胃癌脑转移难以治疗，预后较差。尽管有各种可能的治疗方法，但此类患者的生存率仍不理想；因此，需要探索新的治疗方法或联合治疗方案。
病例介绍
我们在此讨论了一名 38 岁男性的病例，该患者最初被诊断为胃癌脑转移。起初，仅进行了立体定向放射外科（SRS）治疗，但效果不佳。脑部和全身转移进展后，联合 SRS 和抗 PD-1 治疗，脑部和腹内转移性病变得到了满意的缓解。
结论
抗 PD-1 治疗联合 SRS 对胃癌脑转移可能有效。
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