Joyce J N, Loeschen S K, Sapp D W, Marshall J F
Brain Res. 1986 Jul 16;378(1):158-63. doi: 10.1016/0006-8993(86)90298-2.
Senescent (26-28 months) Fischer 344 rats were shown to have a lower density of D2 sites (-36%) without any change in affinity in membranes prepared from homogenized caudate-putamen (CPU), as compared to young adult (5-6 months) rats. In additional rats prepared for quantitative autoradiography of [3H]spiroperidol binding, the loss was shown to be specific for and quite extensive (50-60%) in the lateral to ventrolateral region of the CPU. The region of the CPU that shows the major age-related loss of D2 sites is critically involved in sensorimotor functions; therefore this regional loss of D2 sites may contribute importantly to the sensorimotor deficits in aged rats.
与年轻成年（5 - 6个月）大鼠相比，衰老（26 - 28个月）的Fischer 344大鼠尾状核 - 壳核（CPU）匀浆制备的膜中D2位点密度较低（-36%），亲和力无变化。在另外准备用于[3H]螺哌啶醇结合定量放射自显影的大鼠中，这种损失在CPU的外侧到腹外侧区域表现为特异性且相当广泛（50 - 60%）。显示出与年龄相关的D2位点主要损失的CPU区域在感觉运动功能中起关键作用；因此，D2位点的这种区域损失可能对老年大鼠的感觉运动缺陷有重要影响。
