Itoh H, Nakao K, Morii N, Yamada T, Shiono S, Sakamoto M, Sugawara A, Saito Y, Katsuura G, Shiomi T
Brain Res Bull. 1986 May;16(5):745-9. doi: 10.1016/0361-9230(86)90147-4.
The effect of intracerebroventricular administration of atrial natriuretic polypeptide on blood pressure was studied in conscious, unrestrained rats. The intracerebroventricular injection of alpha-human atrial natriuretic polypeptide did not promote any significant change in basal blood pressure, whereas it attenuated central angiotensin II-induced pressor response in a dose-dependent manner. The plasma atrial natriuretic polypeptide level did not change after the central administration of alpha-human atrial natriuretic polypeptide. These data implicate atrial natriuretic polypeptide as a factor in blood pressure regulation in the central nervous system.
在清醒、不受束缚的大鼠中研究了脑室内注射心房利钠多肽对血压的影响。脑室内注射α-人心房利钠多肽并未引起基础血压的任何显著变化，而它以剂量依赖的方式减弱了中枢血管紧张素II诱导的升压反应。中枢给予α-人心房利钠多肽后，血浆心房利钠多肽水平没有变化。这些数据表明心房利钠多肽是中枢神经系统中血压调节的一个因素。
