Komatsu K, Nakamura W
C R Seances Soc Biol Fil. 1986;180(1):117-20.
Combined effects of cis-DDP and OK-432 on the ascites mastocytoma was studied in mice laying emphasis on the best timing for the administration of the OK-432. Mice were transplanted with FMA3 mastocytoma cells into the abdominal cavity at a dose of 10(5) cells per mouse. They were injected with cis-DDP next day at a single shot of 8 mg/kg in the abdominal cavity. A streptococcal preparation, OK-432, was i.p. injected two times at intervals of one week at a dose of 50 KE/kg per injection. The pair of injections started 1, 2, 3, 4 or 5 weeks after the transplantation. Mean survival time (M. S. T.) of mice was 16.8, 16.2 and 52.3 in the groups of mice nontreated, given OK-432 alone, and given cis-DDP alone, respectively. In comparison of M. S. T. within the groups of mice treated with the combination of cis-DDP and OK-432, the highest value was observed in the group which was given OK-432 between 3 and 4 weeks after the transplantation.
研究了顺铂（cis-DDP）和溶链菌制剂（OK-432）联合作用对小鼠腹水型肥大细胞瘤的影响，重点关注OK-432给药的最佳时机。将FMA3肥大细胞瘤细胞以每只小鼠10(5)个细胞的剂量移植到小鼠腹腔。次日腹腔注射一次顺铂，剂量为8mg/kg。溶链菌制剂OK-432腹腔注射，每次剂量为50KE/kg，每周注射两次。在移植后1、2、3、4或5周开始进行这两次注射。未治疗组、单独给予OK-432组和单独给予顺铂组小鼠的平均生存时间（M.S.T.）分别为16.8、16.2和52.3天。在顺铂与OK-432联合治疗组中比较M.S.T.，发现移植后3至4周给予OK-432的组中M.S.T.值最高。
