Nakamura W, Komatsu K, Kita M, Kishida T
C R Seances Soc Biol Fil. 1986;180(5):601-8.
Effects of preheating and injection of cis-DDP (CDDP) or interferon on tumor-induced sensitization to systemic hyperthermia (SH) was investigated in mice. LD50 of SH at 42.0 +/- 0.2 degrees C (core body temperature) was 43 min in normal mice and 8 min in mice which were i.p. transplanted with FMA3 cells at a dose of 10(5) one day before. In mice which had received the SH for 10 min one hour before, one hour after or one day before the transplantation, LD50 of the SH one day after the transplantation was 41, 35 and 22 min, respectively. An injection of CDDP given i.p. at a dose of 4 mg/kg one day after the transplantation, which was effective to kill about 99% of the tumor cells, did not change the course of thermosensitization after the transplantation. An i.p. injection of mouse interferon did not change the thermosensitivity of normal mice, but greatly suppressed the thermosensitizing effect of tumor cells when it was given one day before the transplantation.
研究了预热和顺铂（CDDP）或干扰素注射对小鼠肿瘤诱导的全身热疗（SH）敏感性的影响。在核心体温为42.0±0.2℃时，正常小鼠SH的半数致死时间（LD50）为43分钟，而在移植前一天腹腔注射10⁵个FMA3细胞的小鼠中为8分钟。在移植前1小时、移植后1小时或移植前1天接受10分钟SH的小鼠中，移植后1天SH的LD50分别为41分钟、35分钟和22分钟。移植后1天腹腔注射4mg/kg剂量的CDDP，可有效杀死约99%的肿瘤细胞，但并未改变移植后的热敏感进程。腹腔注射小鼠干扰素不会改变正常小鼠的热敏感性，但在移植前1天给予时，可显著抑制肿瘤细胞的热敏感作用。
