Institute for Biogenesis Research, University of Hawaii, Honolulu, HI, United States.
Honolulu Heart Program/Honolulu-Asia Aging Study, Kuakini Medical Center, Honolulu, HI, United States; Ohana Genetics, Honolulu, HI, United States.
Curr Top Dev Biol. 2018;127:193-212. doi: 10.1016/bs.ctdb.2017.10.001.
Aging is a complex, multifactorial process with significant plasticity. While several biological pathways appear to influence aging, few genes have been identified that are both evolutionarily conserved and have a strong impact on aging and age-related phenotypes. The FoxO3 gene (FOXO3), and its homologs in model organisms, appears especially important, forming a key gene in the insulin/insulin-like growth factor-signaling pathway, and influencing life span across diverse species. We highlight some of the key findings that are associated with FoxO3 protein, its gene and homologs in relation to lifespan in different species, and the insights these findings might provide about the molecular, cellular, and physiological processes that modulate aging and longevity in humans.
衰老是一个复杂的、多因素的过程，具有显著的可塑性。虽然有几种生物途径似乎会影响衰老，但很少有基因被确定为既具有进化保守性又对衰老和与年龄相关的表型有强烈影响。FoxO3 基因（FOXO3）及其在模式生物中的同源物似乎尤为重要，它构成了胰岛素/胰岛素样生长因子信号通路中的关键基因，并影响了不同物种的寿命。我们强调了一些与 FoxO3 蛋白及其在不同物种中的基因和同源物相关的关键发现，以及这些发现可能为调节人类衰老和长寿的分子、细胞和生理过程提供的见解。
