二甲双胍作为一种针对衰老的工具。
Metformin as a Tool to Target Aging.
作者信息
Barzilai Nir, Crandall Jill P, Kritchevsky Stephen B, Espeland Mark A
机构信息
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Cell Metab. 2016 Jun 14;23(6):1060-1065. doi: 10.1016/j.cmet.2016.05.011.
Abstract
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.
摘要
为了在众多模型中延长寿命和健康期，衰老已成为基因、饮食调控及药物作用的目标。二甲双胍已在人体试验中显示出对多种与年龄相关疾病的保护作用，它将在“用二甲双胍靶向衰老”（TAME）试验中接受测试，这是开发更有效下一代药物的第一步。
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