基因表达在异源多倍体中的优势：假说和模型。

Gene Expression Dominance in Allopolyploids: Hypotheses and Models.

机构信息

Matière et Systèmes Complexes, UMR 7057, Paris 75013, France; Université Paris Diderot-Paris VII, 75205 Paris Cedex 13, France; These authors contributed equally to this work.

School of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK; These authors contributed equally to this work.

出版信息

Trends Plant Sci. 2018 May;23(5):393-402. doi: 10.1016/j.tplants.2018.01.002. Epub 2018 Feb 9.

DOI:10.1016/j.tplants.2018.01.002

PMID:29433919

Abstract

The classical example of nonadditive contributions of the two parents to allopolyploids is nucleolar dominance, which entails silencing of one parental set of ribosomal RNA genes. This has been observed for many other loci. The prevailing explanation for this genome-wide expression disparity is that the two merged genomes differ in their transposable element (TE) complement and in their level of TE-mediated repression of gene expression. Alternatively, and not exclusively, gene expression dominance may arise from mismatches between trans effectors and their targets. Here, we explore quantitative models of regulatory mismatches leading to gene expression dominance. We also suggest that, when pairs of merged genomes are similar from one allopolyploidization event to another, gene-level and genome dominance patterns should also be similar.

摘要

双亲中非加性贡献的经典例子是核仁优势，它导致一组核糖体 RNA 基因的沉默。这在许多其他基因座中都有观察到。对于这种全基因组表达差异的主要解释是，两个合并的基因组在转座元件 (TE) 组成和 TE 介导的基因表达抑制水平上存在差异。或者，（并非排他性地），基因表达优势可能源于转录因子与其靶标的不匹配。在这里，我们探索了导致基因表达优势的调控不匹配的定量模型。我们还表明，当一对合并的基因组在从一次异源多倍化事件到另一次事件时相似时，基因水平和基因组优势模式也应该相似。