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基于吡唑的磺酰胺衍生物的合成、抗菌及抗氧化活性

Synthesis, Antimicrobial and Antioxidant Activity of Pyrazole Based Sulfonamide Derivatives.

作者信息

Badgujar Jagdish R, More Dhananjay H, Meshram Jyotsna S

机构信息

1School of Chemical Sciences, North Maharashtra University, Jalgaon, 425001 India.

2Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, 440033 India.

出版信息

Indian J Microbiol. 2018 Mar;58(1):93-99. doi: 10.1007/s12088-017-0689-6. Epub 2017 Oct 31.

DOI:10.1007/s12088-017-0689-6
PMID:29434402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5801178/
Abstract

A series of new sulfonamides have been synthesized from Ampyrone with different benzene sulfonyl chlorides to yield the -1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1-pyrazol-4-yl) benzenesulfonamides (-). All synthesized compounds were characterized on the basis of FTIR, H NMR, and C NMR, and also by the aid of mass spectral data. Further, all synthesized compounds have studied for their in vitro antimicrobial activities against selected bacterial as well as fungal strains by the agar well diffusion method. Free radical scavenging activity has been investigated by using DPPH method. Among all the synthesized compounds, , , and exhibited significant antimicrobial and antioxidant activities.

摘要

一系列新的磺胺类化合物由安替比林与不同的苯磺酰氯合成，得到(-)-1,5-二甲基-3-氧代-2-苯基-2,3-二氢-1-吡唑-4-基)苯磺酰胺。所有合成的化合物均通过傅里叶变换红外光谱(FTIR)、氢核磁共振(H NMR)和碳核磁共振(C NMR)以及质谱数据进行表征。此外，通过琼脂孔扩散法研究了所有合成化合物对选定细菌和真菌菌株的体外抗菌活性。采用二苯基苦味酰基自由基(DPPH)法研究了自由基清除活性。在所有合成的化合物中，[具体化合物名称未给出]表现出显著的抗菌和抗氧化活性。