Department of Ultrasound, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
World J Gastroenterol. 2018 Feb 7;24(5):602-612. doi: 10.3748/wjg.v24.i5.602.
To investigate the interactions of the DNA repair gene excision repair cross complementing group 5 () and the metabolic gene glutathione S-transferase pi 1 () and their effects on atrophic gastritis (AG) and gastric cancer (GC) risk.
Seven single nucleotide polymorphisms (SNPs) (rs1047768, rs2094258, rs2228959, rs4150291, rs4150383, rs751402, and rs873601) and SNP rs1695 were detected using the Sequenom MassARRAY platform in 450 GC patients, 634 AG cases, and 621 healthy control subjects in a Chinese population.
Two pairwise combinations ( rs2094258 and rs873601 with rs1695) influenced AG risk ( = 0.008 and 0.043, respectively), and the ERCC5 rs2094258-GSTP1 rs1695 SNP pair demonstrated an antagonistic effect, while rs873601- rs1695 showed a synergistic effect on AG risk OR = 0.51 and 1.79, respectively). No pairwise combinations were observed in relation to GC risk. There were no cumulative effects among the pairwise interactions ( rs2094258 and rs873601 with rs1695) on AG susceptibility ( > 0.05). When the modification effect of () infection was evaluated, the cumulative effect of one of the aforementioned pairwise interactions ( rs873601- rs1695) was associated with an increased AG risk in the case of negative status ( = 0.043).
There is a multifarious interaction between the DNA repair gene SNPs (rs2094258 and rs873601) and the metabolic gene rs1695, which may form the basis for various inter-individual susceptibilities to AG.
研究 DNA 修复基因切除修复交叉互补组 5（）和代谢基因谷胱甘肽 S-转移酶 pi 1（）的相互作用及其对萎缩性胃炎（AG）和胃癌（GC）风险的影响。
在中国人群中，采用Sequenom MassARRAY 平台检测 450 例 GC 患者、634 例 AG 病例和 621 例健康对照者的 7 个单核苷酸多态性（SNP）（rs1047768、rs2094258、rs2228959、rs4150291、rs4150383、rs751402 和 rs873601）和 SNP rs1695。
两个双等位基因组合（rs2094258 和 rs873601 与 rs1695）影响 AG 风险（=0.008 和 0.043），ERCC5 rs2094258-GSTP1 rs1695 SNP 对显示拮抗作用，而 rs873601-rs1695 对 AG 风险的 OR 值分别为 0.51 和 1.79。未观察到与 GC 风险相关的双等位基因组合。在 AG 易感性方面，双等位基因相互作用（rs2094258 和 rs873601 与 rs1695）之间没有累积效应（>0.05）。当评估 （）感染的修饰作用时，上述双等位基因相互作用之一（rs873601-rs1695）的累积效应与 （）阴性状态下 AG 风险增加相关（=0.043）。
DNA 修复基因 SNP（rs2094258 和 rs873601）和代谢基因 rs1695 之间存在复杂的相互作用，可能是导致个体对 AG 易感性不同的基础。
