Zhao Yong, Liu Jia-Guo, Chen Wei-Min, Yu Ai-Xi
Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.
Department of Orthopedics, Hubei University of Medicine Affiliated Taihe Hospital, Shiyan, Hubei 442000, P.R. China.
Exp Ther Med. 2018 Feb;15(2):1304-1313. doi: 10.3892/etm.2017.5552. Epub 2017 Nov 23.
Wound infection has been a persistent problem that is common and costly. Thermosensitive hydrogel has been demonstrated to be a suitable dressing candidate due to its high moldability, easy administration and ability to maintain a moist topical environment at the wound bed. In the present study, a novel thermosensitive hydrogel was successfully prepared and characterized to have a porous inner structure and a sustained curcumin-releasing profile. The wound healing ability of the hydrogel was investigated in a wound infection model in rats. On analysis, it was observed that the hydrogel complex-dressed wounds exhibited a faster wound closure rate compared with gauze-covered wounds, which was paralleled with improved histological outcomes that were observed. Additionally, the results of antimicrobial, anti-oxidant, western blot analysis and reverse transcription-quantitative polymerase chain reaction assays indicated that the hydrogel complex had distinct anti-oxidative, antimicrobial and anti-nuclear factor-κB-signaling capacities. These results suggest that this novel hydrogel may be a suitable candidate for facilitating the healing of infected cutaneous wounds in rats.
伤口感染一直是一个常见且代价高昂的持续性问题。热敏水凝胶因其高可塑性、易于应用以及能够在伤口床维持湿润的局部环境而被证明是一种合适的敷料候选物。在本研究中，成功制备了一种新型热敏水凝胶，并对其进行表征，发现其具有多孔内部结构和持续的姜黄素释放曲线。在大鼠伤口感染模型中研究了该水凝胶的伤口愈合能力。经分析，观察到与纱布覆盖的伤口相比，水凝胶复合物敷料的伤口表现出更快的伤口闭合率，同时观察到组织学结果得到改善。此外，抗菌、抗氧化、蛋白质印迹分析和逆转录-定量聚合酶链反应测定的结果表明，水凝胶复合物具有独特的抗氧化、抗菌和抗核因子-κB信号传导能力。这些结果表明，这种新型水凝胶可能是促进大鼠感染性皮肤伤口愈合的合适候选物。
