Madamsetty Vijay Sagar, Vazifehdoost Maryam, Alhashemi Samira Hossaini, Davoudi Hesam, Zarrabi Ali, Dehshahri Ali, Fekri Hojjat Samareh, Mohammadinejad Reza, Thakur Vijay Kumar
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, Florida 32224, United States.
Department of Toxicology & Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Kerman 6718773654, Iran.
ACS Omega. 2023 Feb 28;8(10):8960-8976. doi: 10.1021/acsomega.2c07062. eCollection 2023 Mar 14.
Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.
自1949年首次报道姜黄素的药理活性以来，大量研究报告了这种存在于膳食香料姜黄中的天然多酚的多种活性。然而，姜黄素尚未作为一种获批药物用于人类。姜黄素的临床转化因其低溶解度和生物利用度而受到阻碍。通过使用药物递送系统对姜黄素进行制剂，可以提高其生物利用度和溶解度。具有生物相容性和低毒性作用的水凝胶已对疏水性药物成功制剂用于人体临床试验产生了重大影响。本综述重点关注基于水凝胶的姜黄素递送系统，并描述其作为抗癌剂和伤口愈合剂的应用。
