Yu Xin, Zhang Na, Lin Wanfu, Wang Chen, Gu Wei, Ling Changquan, Feng Yinglu, Su Yonghua
Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, P.R. China.
Department of Traditional Chinese Medicine, 401 Hospital of The Chinese People's Liberation Army, Qingdao, Shandong 266071, P.R. China.
Exp Ther Med. 2018 Feb;15(2):2097-2103. doi: 10.3892/etm.2017.5657. Epub 2017 Dec 18.
Ginsenosides Rb1, Rh1, Rg1 and Rg3 are known as the main active components extracted from the roots of the Panax ginseng C.A. Meyer, and were reported to have immunoregulatory effects. Disruption of B-cell immune regulation during the pathogenesis of systemic lupus erythematosus (SLE) may lead to the production of large amounts of antibodies. The present study investigated the effects of the four ginsenoside monomers on B-cell immune regulation and observed that they inhibited the proliferation and secretion of B cells induced by LPS, caused an upregulation of the expression of apoptosis-associated proteins Fas/Fas ligand and caspase-3, the expression of FcγRIIB (CD32) as well as the proportion of inactive B cells (CD19CD27). These results indicate that Rb1, Rh1, Rg1 and Rg3 inhibit the humoral immunity of SLE, among which Rh1 exhibited the most obvious inhibitory effect.
人参皂苷Rb1、Rh1、Rg1和Rg3是从五加科植物人参（Panax ginseng C.A. Meyer）根中提取的主要活性成分，据报道具有免疫调节作用。系统性红斑狼疮（SLE）发病机制中B细胞免疫调节的破坏可能导致大量抗体的产生。本研究调查了这四种人参皂苷单体对B细胞免疫调节的影响，观察到它们抑制了LPS诱导的B细胞增殖和分泌，导致凋亡相关蛋白Fas/Fas配体和caspase-3的表达上调、FcγRIIB（CD32）的表达以及无活性B细胞（CD19CD27）的比例增加。这些结果表明，Rb1、Rh1、Rg1和Rg3抑制SLE的体液免疫，其中Rh1表现出最明显的抑制作用。
