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苦参碱通过Wnt/β-连环蛋白通路下调血管内皮生长因子对乳腺癌的作用。

Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway.

作者信息

Xiao Xu, Ao Man, Xu Fan, Li Xiao, Hu Jiuli, Wang Ying, Li Daixiao, Zhu Xiaoqin, Xin Chunlan, Shi Wenda

机构信息

Department of Pharmacy, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China.

Department of Oncology, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China.

出版信息

Oncol Lett. 2018 Feb;15(2):1691-1697. doi: 10.3892/ol.2017.7519. Epub 2017 Dec 5.

DOI:10.3892/ol.2017.7519
PMID:29434864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5776934/
Abstract

The aim of the present study was to investigate the effect of matrine on breast cancer and its underlying mechanism. Matrine is a major component of , exhibited antitumor activity in a number of neoplasms, including breast cancer. The present study revealed that matrine inhibited cell viability and induced apoptosis in 4T1 and MCF-7 cells in a dose- and time-dependent manner . In addition, matrine suppressed the 4T1-tumor growth, induced apoptosis, inhibited the expression of vascular endothelial growth factor and downregulated the Wnt/β-catenin signaling pathway . All these findings indicated that matrine may be a novel effective candidate for the treatment of breast cancer.

摘要

本研究的目的是探讨苦参碱对乳腺癌的影响及其潜在机制。苦参碱是[具体植物名称]的主要成分，在包括乳腺癌在内的多种肿瘤中表现出抗肿瘤活性。本研究表明，苦参碱以剂量和时间依赖性方式抑制4T1和MCF-7细胞的活力并诱导其凋亡。此外，苦参碱抑制4T1肿瘤生长、诱导凋亡、抑制血管内皮生长因子的表达并下调Wnt/β-连环蛋白信号通路。所有这些发现表明，苦参碱可能是治疗乳腺癌的一种新型有效候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/2ed89b8dfe33/ol-15-02-1691-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/4148747b413e/ol-15-02-1691-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/59b38dd23309/ol-15-02-1691-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/ad5fa73f2af2/ol-15-02-1691-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/60beadeb762c/ol-15-02-1691-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/2ed89b8dfe33/ol-15-02-1691-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/4148747b413e/ol-15-02-1691-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/59b38dd23309/ol-15-02-1691-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/ad5fa73f2af2/ol-15-02-1691-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/60beadeb762c/ol-15-02-1691-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bde/5776934/2ed89b8dfe33/ol-15-02-1691-g04.jpg

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