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天然产物在预防肿瘤耐药及相关信号通路中的作用。

Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways.

机构信息

Department of Head-Neck and Breast Surgery, Yuebei People's Hospital of Shantou University, Shaoguan 512027, China.

Affiliated Foshan Maternity and Chlid Healthcare Hospital, Southern Medical University, Foshan 528000, China.

出版信息

Molecules. 2022 May 30;27(11):3513. doi: 10.3390/molecules27113513.

DOI:10.3390/molecules27113513
PMID:35684449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9181879/
Abstract

Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor treatment. The emergence of tumor drug resistance has always been a main concern of oncologists. Therefore, overcoming tumor drug resistance and looking for new strategies for tumor treatment is a major focus in the field of tumor research. Natural products serve as effective substances against drug resistance because of their diverse chemical structures and pharmacological effects. We reviewed the signaling pathways involved in the development of tumor drug resistance, including Epidermal growth factor receptor (EGFR), Renin-angiotensin system (Ras), Phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), Wnt, Notch, Transforming growth factor-beta (TGF-β), and their specific signaling pathway inhibitors derived from natural products. This can provide new ideas for the prevention of drug resistance in cancer therapy.

摘要

耐药性仍然是癌症治疗中的一个障碍，导致肿瘤治疗的失败。肿瘤耐药性的出现一直是肿瘤学家关注的主要问题。因此，克服肿瘤耐药性并寻找肿瘤治疗的新策略是肿瘤研究领域的一个重点。由于其多样的化学结构和药理作用，天然产物是对抗耐药性的有效物质。我们综述了参与肿瘤耐药性发展的信号通路，包括表皮生长因子受体（EGFR）、肾素-血管紧张素系统（Ras）、磷脂酰肌醇-3-激酶/蛋白激酶 B（PI3K/Akt）、Wnt、Notch、转化生长因子-β（TGF-β）及其来自天然产物的特定信号通路抑制剂。这可为癌症治疗中预防耐药性提供新的思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc79/9181879/860986372f61/molecules-27-03513-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc79/9181879/860986372f61/molecules-27-03513-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc79/9181879/860986372f61/molecules-27-03513-g001.jpg

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Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways.

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本文引用的文献

[1]
Scope of organometallic compounds based on transition metal-arene systems as anticancer agents: starting from the classical paradigm to targeting multiple strategies.

RSC Adv. 2019-1-24

[2]
Icaritin Inhibits Migration and Invasion of Human Ovarian Cancer Cells the Akt/mTOR Signaling Pathway.

Front Oncol. 2022-4-1

[3]
Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance.

Front Cell Dev Biol. 2022-3-24

[4]
Therapeutic Drug Monitoring of Tyrosine Kinase Inhibitors Using Dried Blood Microsamples.

Front Oncol. 2022-3-22

[5]
Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429.

Front Genet. 2022-3-3

[6]
Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene. 2022-4

[7]
Construction of immune-related lncRNA signature to predict aggressiveness, immune landscape, and drug resistance of colon cancer.

BMC Gastroenterol. 2022-3-17

[8]
Sesquiterpene Lactones Attenuate Paclitaxel Resistance Via Inhibiting MALAT1/STAT3/ FUT4 Axis and P-Glycoprotein Transporters in Lung Cancer Cells.

Front Pharmacol. 2022-2-24

[9]
Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles.

Eur J Med Chem. 2022-3-15

[10]
IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment.

Int J Mol Sci. 2022-2-5

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