Guo Yuqi, Wei Fang, Wang Juan, Zhao Yingxin, Sun Shangwen, Zhang Hua, Liu Zhendong
Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
Department of Cardiology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, China.
Oncotarget. 2018 Jan 2;9(4):5251-5262. doi: 10.18632/oncotarget.23825. eCollection 2018 Jan 12.
Hemodynamic has increasingly been regarded as an important factor of renal function. However, the relationship between carotid artery wall shear stress (WSS) and renal function is not clarified. To investigate the relationship between carotid WSS and renal function, we recruited 761 older subjects aged 60 years and over from community-dwelling in the Shandong area, China. Carotid WSS, endothelial function, and estimated glomerular filtration rate (eGFR) were assessed in all subjects. Subjects were grouped by the interquartile of the carotid artery mean WSS. We found that the eGFRs derived from serum creatinine and/or cystatin C using three CKD-EPI equations were significantly higher and albumin/creatinine ratio was lower in the higher interquartile groups than in the lower interquartile groups ( <0.05). The mean WSS was independently correlated with eGFRs even after adjustment for confounders. Similar findings were found between carotid artery peak WSS and eGFRs and albumin/creatinine ratio. In addition, we found that endothelial function was strongly related to carotid WSS and renal function after adjustment for confounders. In conclusion, there is an independent correlation of carotid WSS with renal function in the elderly. The local rheologic forces may play an important role in renal function changing. The correlation may be mediated by regulation of endothelial function.
血流动力学越来越被视为肾功能的一个重要因素。然而，颈动脉壁剪切应力（WSS）与肾功能之间的关系尚未明确。为了研究颈动脉WSS与肾功能之间的关系，我们从中国山东地区的社区居民中招募了761名60岁及以上的老年受试者。对所有受试者评估颈动脉WSS、内皮功能和估计肾小球滤过率（eGFR）。根据颈动脉平均WSS的四分位数间距对受试者进行分组。我们发现，使用三个CKD-EPI方程从血清肌酐和/或胱抑素C得出的eGFR在较高四分位数组中显著高于较低四分位数组，且白蛋白/肌酐比值较低（<0.05）。即使在对混杂因素进行调整后，平均WSS仍与eGFR独立相关。在颈动脉峰值WSS与eGFR以及白蛋白/肌酐比值之间也发现了类似的结果。此外，我们发现，在对混杂因素进行调整后，内皮功能与颈动脉WSS和肾功能密切相关。总之，老年人的颈动脉WSS与肾功能存在独立相关性。局部流变学力量可能在肾功能变化中起重要作用。这种相关性可能由内皮功能的调节介导。
