Hu Haochang, Li Bin, Zhou Cong, Ying Xiuru, Chen Min, Huang Tianyi, Chen Yuehong, Ji Huihui, Pan Ranran, Wang Tiangong, Jiang Danjie, Chen Yanfei, Yang Yong, Duan Shiwei
Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.
Oncotarget. 2018 Jan 3;9(4):5378-5386. doi: 10.18632/oncotarget.23870. eCollection 2018 Jan 12.
As a common antagonist of Wnt/β-catenin signaling, Wnt inhibitory factor 1 () plays an important role in the tumor progression. The aim of our meta-analysis was to summarize the diagnostic value of methylation in colorectal cancer (CRC). Eligible studies were retrieved by a systemic search among PubMed, Embase, CNKI, and Wanfang literature databases. The diagnostic value of methylation for CRC was assessed by the summary receiver operating characteristics (SROC) test. Our meta-analysis of 12 studies between 1420 CRC samples and 946 control samples showed that hypermethylation was significantly associated with CRC ( < 0.001, OR = 30.10, 95% CI = 19.48-46.50). hypermethylation, as a diagnostic biomarker for CRC, has a pooled sensitivity of 0.40 (95% CI: 0.37-0.42), a pooled specificity of 0.95 (95% CI: 0.93-0.96), a pooled positive-likelihood ratio (PLR) of 8.65 (95% CI, 4.47-16.73), and a pooled negative-likelihood ratio (NLR) of 0.41 (95% CI, 0.30-0.55), a diagnostic odds ratio (DOR) of 26.86 (95% CI: 15.73-45.89), and an area under the curve (AUC) of 0.9115. In conclusion, our study established that hypermethylation might be a promising diagnostic biomarker for CRC.
作为Wnt/β-连环蛋白信号通路的常见拮抗剂，Wnt抑制因子1（WIF-1）在肿瘤进展中起重要作用。我们的荟萃分析旨在总结WIF-1甲基化在结直肠癌（CRC）中的诊断价值。通过对PubMed、Embase、中国知网和万方文献数据库进行系统检索，获取符合条件的研究。采用汇总受试者工作特征（SROC）试验评估WIF-1甲基化对CRC的诊断价值。我们对12项研究（涉及1420例CRC样本和946例对照样本）的荟萃分析表明，WIF-1高甲基化与CRC显著相关（P<0.001，OR=30.10，95%CI=19.48-46.50）。WIF-1高甲基化作为CRC的诊断生物标志物，汇总敏感性为0.40（95%CI：0.37-0.42），汇总特异性为0.95（95%CI：0.93-0.96），汇总阳性似然比（PLR）为8.65（95%CI，4.47-16.73），汇总阴性似然比（NLR）为0.41（95%CI，0.30-0.55），诊断比值比（DOR）为26.86（95%CI：15.73-45.89），曲线下面积（AUC）为0.9115。总之，我们的研究表明WIF-1高甲基化可能是CRC一种有前景的诊断生物标志物。
