Prasanna Rammohan, Bunger Deepak, Khan Mujtaba A
Consultant Medical Oncologist, Department of Medical Oncology, CBCC-GVN Cancer Center, Tiruchirapalli, Tamil Nadu 620005, India.
Department of Medical Affairs and Clinical Development, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380059, India.
Mol Clin Oncol. 2018 Feb;8(2):296-299. doi: 10.3892/mco.2017.1519. Epub 2017 Nov 27.
The standard of care for locally advanced cervical cancer has been the combination of a taxane with platinum based therapy. Conventional docetaxel is known to cause hypersensitivity reactions, fluid retention and other toxicities due to polysorbate-80 and ethanol. Corticosteroid premedication prior to docetaxel administration is required to prevent these toxicities, however, toxicities are still observed, sometimes fatal, despite premedication. DoceAqualip, a nanosomal docetaxel lipid suspension, developed with lipids generally regarded as safe (GRAS) by the US Food and Drug Administration, is devoid of polysorbate-80 and ethanol. DoceAqualip has been demonstrated to be effective and well-tolerated in various cancer types. The authors' report a case of a patient with Stage IIIB cervical cancer who was treated with carboplatin and DoceAqualip (concurrent ChemoRT) and achieved complete response without any serious adverse events.
局部晚期宫颈癌的标准治疗方案是紫杉烷类与铂类疗法联合使用。众所周知，传统多西他赛会因聚山梨酯80和乙醇导致过敏反应、液体潴留及其他毒性。多西他赛给药前需要使用皮质类固醇进行预处理以预防这些毒性，然而，尽管进行了预处理，仍会观察到毒性，有时甚至是致命的。DoceAqualip是一种纳米脂质体多西他赛悬浮液，由美国食品药品监督管理局认定为一般认为安全（GRAS）的脂质制成，不含聚山梨酯80和乙醇。DoceAqualip已被证明在多种癌症类型中有效且耐受性良好。作者报告了一例IIIB期宫颈癌患者，该患者接受了卡铂和DoceAqualip治疗（同步放化疗），并实现了完全缓解，且未出现任何严重不良事件。
