Ramaswamy Rajkumar, Joshi Nisarg, Khan Mujtaba A, Siddhara Seerin
Department of Medical Oncology, Velammal Medical College and Research Institute, Madurai, Tamil Nadu 625009, India.
Department of Medical Affairs & Clinical Development, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380054, India.
Onco Targets Ther. 2019 Jul 15;12:5679-5685. doi: 10.2147/OTT.S206573. eCollection 2019.
The current report presents a case of a pregnant woman with breast cancer metastasized to liver and lungs. The standard of care for breast cancer in pregnancy is anthracycline/taxane-based chemotherapy regimens. Docetaxel has shown a favorable toxicity profile during the second and third trimesters of pregnancy. A novel nanosomal docetaxel lipid suspension (NDLS) (DoceAqualip), with a proven efficacy and tolerability profile, has been approved in India for the treatment of advanced solid tumors since 2013. We present here a case of a pregnant woman with metastatic breast cancer managed with NDLS based TAC regimen showing a partial response after six cycles. The patient delivered a healthy male child with normal Apgar score and weight at the 32nd week of gestation.
本报告介绍了一例乳腺癌转移至肝脏和肺部的孕妇病例。孕期乳腺癌的标准治疗方案是基于蒽环类/紫杉烷类的化疗方案。多西他赛在妊娠中期和晚期显示出良好的毒性特征。一种新型纳米脂质体多西他赛混悬液(NDLS)(多西他赛脂质体)自2013年以来已在印度获批用于治疗晚期实体瘤,其疗效和耐受性已得到证实。我们在此报告一例转移性乳腺癌孕妇,采用基于NDLS的TAC方案治疗,六个周期后显示部分缓解。患者在妊娠第32周分娩了一名健康男婴,阿氏评分和体重正常。