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纳米粒多西他赛脂质混悬液用于妊娠转移性乳腺癌患者的化疗——病例报告

Nanosomal docetaxel lipid suspension based chemotherapy in a pregnant MBC patient - a case report.

作者信息

Ramaswamy Rajkumar, Joshi Nisarg, Khan Mujtaba A, Siddhara Seerin

机构信息

Department of Medical Oncology, Velammal Medical College and Research Institute, Madurai, Tamil Nadu 625009, India.

Department of Medical Affairs & Clinical Development, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380054, India.

出版信息

Onco Targets Ther. 2019 Jul 15;12:5679-5685. doi: 10.2147/OTT.S206573. eCollection 2019.

Abstract

The current report presents a case of a pregnant woman with breast cancer metastasized to liver and lungs. The standard of care for breast cancer in pregnancy is anthracycline/taxane-based chemotherapy regimens. Docetaxel has shown a favorable toxicity profile during the second and third trimesters of pregnancy. A novel nanosomal docetaxel lipid suspension (NDLS) (DoceAqualip), with a proven efficacy and tolerability profile, has been approved in India for the treatment of advanced solid tumors since 2013. We present here a case of a pregnant woman with metastatic breast cancer managed with NDLS based TAC regimen showing a partial response after six cycles. The patient delivered a healthy male child with normal Apgar score and weight at the 32nd week of gestation.

摘要

本报告介绍了一例乳腺癌转移至肝脏和肺部的孕妇病例。孕期乳腺癌的标准治疗方案是基于蒽环类/紫杉烷类的化疗方案。多西他赛在妊娠中期和晚期显示出良好的毒性特征。一种新型纳米脂质体多西他赛混悬液(NDLS)(多西他赛脂质体)自2013年以来已在印度获批用于治疗晚期实体瘤,其疗效和耐受性已得到证实。我们在此报告一例转移性乳腺癌孕妇,采用基于NDLS的TAC方案治疗,六个周期后显示部分缓解。患者在妊娠第32周分娩了一名健康男婴,阿氏评分和体重正常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf5/6642620/0c02e306090e/OTT-12-5679-g0001.jpg

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