Chen Liyan, Oh Hyerim, Wu Di, Kim Myung Hwa, Yoon Juyoung
Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Korea.
Chem Commun (Camb). 2018 Feb 27;54(18):2276-2279. doi: 10.1039/c7cc09901k.
An ESIPT based fluorescent probe, containing a hydroxyphenyl-benzothiazole fluorophore and an oxime reaction site, serves as a selective probe for a nerve gas mimic, diethyl cyanophosphonate (DECP), in solutions and the gas phase. The probe exhibits more than a 60-fold fluorescence enhancement in the presence of the target, has a limit of detection of 1.3 nM and displays high selectivity toward DECP over closely related substances, including sulfur mustard stimulants and other nerve agent mimics. Moreover, composite nanofibers with relatively low concentrations of the probe (0.45% w/w) exhibit distinct color and fluorescence changes upon exposure to DECP vapor.
一种基于激发态质子转移（ESIPT）的荧光探针，含有一个羟基苯基 - 苯并噻唑荧光团和一个肟反应位点，可作为溶液和气相中神经毒气模拟物氰磷酸二乙酯（DECP）的选择性探针。该探针在目标物存在时荧光增强超过60倍，检测限为1.3 nM，对DECP表现出高于包括芥子气模拟物和其他神经毒剂模拟物在内的密切相关物质的高选择性。此外，含有相对低浓度探针（0.45% w/w）的复合纳米纤维在暴露于DECP蒸汽时会出现明显的颜色和荧光变化。
