Dupré A, Christol B, Viraben R
Ann Dermatol Venereol. 1983;110(12):1001-5.
We have recently evaluated eight patients with an unusual genetic dermatosis that was characterized by the development of painful callosities at pressure points of soles, with tender yellowish-brown hyperkeratosis. These lesions are very painful: walking produced pain that was severe. The patients performing manual labor, in addition, had multiple callosities on the palms. Hyperhidrosis of the soles and palms was frequently present. Skin lesions were first noted in adolescence. There was no similar family history. There was no personal nor family history of hair, nail or dental disease. A biopsy was performed in one case and showed a simple hyperkeratosis similar to these observed in callosities. Classification of our cases is difficult. They are not similar to the entity named "hereditary painful callosities" by Roth et al. Review of the literature did not show similar cases. The patients received Etretinate (1 mg/day/kg). In all 8 cases, a dramatic improvement was obtained within seven days; the pain disappeared entirely and the patients were able to walk again without any pain. Then, the per-day dose was diminished without reappearance of the pain.
我们最近评估了8例患有一种罕见遗传性皮肤病的患者，其特征为在脚底受压部位出现疼痛性胼胝，并伴有压痛性黄褐色角化过度。这些皮损非常疼痛：行走时会产生剧痛。此外，从事体力劳动的患者手掌上有多处胼胝。足底和手掌多汗症很常见。皮肤损害最早在青春期被发现。没有类似的家族病史。患者本人及家族均无毛发、指甲或牙齿疾病史。对其中1例进行了活检，结果显示为单纯性角化过度，与胼胝中观察到的情况相似。对我们的病例进行分类很困难。它们与Roth等人命名的“遗传性疼痛性胼胝”不同。文献回顾未发现类似病例。患者接受依曲替酯（1毫克/天/千克）治疗。在所有8例患者中，7天内均有显著改善；疼痛完全消失，患者能够再次行走且毫无疼痛。然后，每日剂量减少，疼痛未再出现。
