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辣椒素通过调节己糖激酶-2 的表达抑制食管鳞癌细胞的糖酵解。

Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression.

机构信息

Department of Gastroenterology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang 317000, P.R. China.

出版信息

Mol Med Rep. 2018 Apr;17(4):6116-6121. doi: 10.3892/mmr.2018.8574. Epub 2018 Feb 8.

Abstract

Capsaicin is a principal component of hot red peppers and chili peppers. Previous studies have reported that capsaicin exhibits antitumor functions in a variety of tumor models. Although various mechanisms underlying the capsaicin‑mediated inhibition of tumor growth have been demonstrated, the impact of capsaicin on tumor metabolism has rarely been reported. The present study demonstrated that capsaicin exhibited an inhibitory effect on tumor glycolysis in esophageal squamous cell carcinoma (ESCC) cells. Following treatment with capsaicin, glucose consumption and lactate production in ESCC cells was decreased. Capsaicin resulted in a decrease of hexokinase‑2 (HK‑2) expression, which is known for its important role in tumor glycolysis. Further investigations demonstrated that phosphatase and tensin homolog (PTEN) expression was increased in ESCC cells treated with capsaicin, and that the RAC‑α serine threonine‑protein kinase signaling pathway was downregulated. In PTEN‑knockdown KYSE150 cells, the decrease in HK‑2 and inhibition of glycolysis caused by capsaicin was attenuated, which suggested that the impact of capsaicin on tumor metabolism was associated with its effect on PTEN.

摘要

辣椒素是红辣椒和辣椒的主要成分。先前的研究报道,辣椒素在多种肿瘤模型中表现出抗肿瘤功能。尽管已经证明了辣椒素介导的肿瘤生长抑制的各种机制,但很少有报道涉及辣椒素对肿瘤代谢的影响。本研究表明,辣椒素对食管鳞状细胞癌(ESCC)细胞的肿瘤糖酵解具有抑制作用。用辣椒素处理后,ESCC 细胞中的葡萄糖消耗和乳酸生成减少。辣椒素导致己糖激酶-2(HK-2)表达降低,其在肿瘤糖酵解中起重要作用。进一步的研究表明,用辣椒素处理的 ESCC 细胞中磷酸酶和张力蛋白同系物(PTEN)的表达增加,RAC-α丝氨酸苏氨酸-蛋白激酶信号通路被下调。在 PTEN 敲低的 KYSE150 细胞中,辣椒素引起的 HK-2 减少和糖酵解抑制作用减弱,这表明辣椒素对肿瘤代谢的影响与其对 PTEN 的作用有关。

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