Lephart Edwin D
Department of Physiology and Developmental Biology and The Neuroscience Center, College of Life Sciences, Brigham Young University, Provo, UT, USA.
J Cosmet Dermatol. 2018 Jun;17(3):282-288. doi: 10.1111/jocd.12508. Epub 2018 Feb 13.
Estrogens are known to have protective and favorable influences on skin health; conversely, androgens oppose the actions of estrogens. Estrogen's chemical messages are transmitted via the classical nuclear hormone estrogen receptors (ER) alpha and beta and the rapid-acting G-coupled membrane estrogen receptor. Androgens [both testosterone and 5α-dihydrotestosterone (5α-DHT)] bind the same androgen receptor. Estrogen levels peak in the mid- to late 20s in women and then decline by 50% by 50 years of age and dramatically decrease further after menopause. The loss of estrogens with aging contributes to diminished dermal health, whereas estrogen hormone therapy [eg, oral conjugated equine estrogens (CEE)] restores skin health. Several reports suggest positive correlations between the levels of circulating estrogens and: (1) perceived age, (2) attractiveness, (3) enhanced skin health, and (4) facial coloration in women. Based upon a psychological dermato-endocrine perspective, the positive correspondence of high estrogens levels with perceived age and facial attractiveness in women especially with aging demonstrates the importance of hormonal influences on observed dermal health and youthful appearance.
已知雌激素对皮肤健康具有保护和有益影响；相反，雄激素则对抗雌激素的作用。雌激素的化学信号通过经典的核激素雌激素受体（ER）α和β以及快速作用的G偶联膜雌激素受体进行传递。雄激素[睾酮和5α-二氢睾酮（5α-DHT）]均与相同的雄激素受体结合。女性雌激素水平在20多岁中后期达到峰值，然后到50岁时下降50%，绝经后进一步大幅下降。随着年龄增长雌激素的流失会导致皮肤健康受损，而雌激素激素疗法[如口服共轭马雌激素（CEE）]可恢复皮肤健康。多项报告表明，循环雌激素水平与以下方面存在正相关：（1）感知年龄，（2）吸引力，（3）皮肤健康增强，以及（4）女性面部肤色。基于心理皮肤内分泌学观点，尤其是随着年龄增长，高雌激素水平与女性感知年龄和面部吸引力之间的正相关关系表明了激素对观察到的皮肤健康和年轻外貌的影响的重要性。
