Baldi E, Conti P, Conti R, Fanciullacci M, Michelacci S, Salmon S, Sicuteri F, Spillantini M G
Int J Clin Pharmacol Res. 1986;6(3):193-7.
Endogenous opioid peptides, by modulating the release of sympathetic transmitters, may play a role in the pathogenesis of migraine and related headaches which are considered hypernociceptive syndromes. Hypoendorphinaemia has been demonstrated in migraine attack. Captopril, a drug able to potentiate morphine analgesia in rats and inhibit enkephalinase in animals and in man, improves the clinical course of migraine. In the present research the cerebrospinal fluid and plasma beta-endorphin (beta-EP) levels have been evaluated following a single oral dose of captopril. The drug increased plasma beta-EP levels in migraine sufferers, and these data may be relevant in the mechanism of action of this drug in migraine and related headaches.
内源性阿片肽可通过调节交感神经递质的释放，在偏头痛及相关头痛（被认为是痛觉过敏综合征）的发病机制中发挥作用。偏头痛发作时已证实存在低内啡肽血症。卡托普利是一种能增强大鼠吗啡镇痛作用并抑制动物和人体脑啡肽酶的药物，可改善偏头痛的临床病程。在本研究中，对单次口服卡托普利后脑脊液和血浆β-内啡肽（β-EP）水平进行了评估。该药物可提高偏头痛患者的血浆β-EP水平，这些数据可能与该药物在偏头痛及相关头痛中的作用机制有关。
