月经相关性偏头痛和癫痫中血浆阿片类物质的模式。

Pattern of plasma opioids in menstrually-related migraine and epilepsy.

作者信息

Facchinetti F, Moglia A, Bonuccelli U, Pozzo P, Martignoni E, Murri L, Genazzani A R

出版信息

Funct Neurol. 1986 Oct-Dec;1(4):415-9.

Abstract

Plasma estradiol (E2), progesterone (P), beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) were measured in the luteal phase of 8 patients affected by menstrually-related migraine (M) and in 3 cases of catamenial epilepsy (CE). Plasma P and E2 of the M patients were lower than in the CE group. Both beta-LPH and beta-EP showed a reduction in M patients near menses, while the opposite pattern was found in CE. These data demonstrate that premenstrual syndrome is sustained by different, neurobiological dysfunction even if endogenous opioids could be involved in both migraine and epilepsy.

摘要

对8例月经相关性偏头痛（M）患者和3例经期癫痫（CE）患者的黄体期血浆雌二醇（E2）、孕酮（P）、β-内啡肽（β-EP）和β-促脂素（β-LPH）进行了测定。M患者的血浆P和E2低于CE组。在M患者中，接近月经期时β-LPH和β-EP均降低，而在CE患者中发现的情况则相反。这些数据表明，即使内源性阿片类物质可能与偏头痛和癫痫都有关，但经前综合征是由不同的神经生物学功能障碍所导致的。