B 细胞靶向治疗慢性移植物抗宿主病。
B-cell targeting in chronic graft-versus-host disease.
机构信息
Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Freiburg University, Freiburg, Germany.
Division of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke Cancer Institute, Duke University Medical Center, Durham, NC; and.
出版信息
Blood. 2018 Mar 29;131(13):1399-1405. doi: 10.1182/blood-2017-11-784017. Epub 2018 Feb 1.
Abstract
Over the last decade, our understanding of the pathophysiology of chronic graft-versus-host disease (cGVHD) has improved considerably. In this spotlight, we discuss emerging insights into the pathophysiology of cGVHD with a focus on B cells. First, we summarize supporting evidence derived from mouse and human studies. Next, novel cGVHD therapy approaches that target B cells will be covered to provide treating physicians with an overview of the rationale behind the emerging armamentarium against cGVHD.
摘要
在过去的十年中，我们对慢性移植物抗宿主病（cGVHD）的病理生理学的理解有了很大的提高。在这个重点介绍中，我们讨论了 cGVHD 病理生理学的新见解，重点是 B 细胞。首先，我们总结了来自小鼠和人类研究的支持证据。接下来，将介绍针对 B 细胞的新型 cGVHD 治疗方法，为治疗医生提供对抗 cGVHD 的新兴武器背后的基本原理概述。
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