Musa Baba Maiyaki, Odoh Chisom N, Galadanci Najibah A, Saidu Hadiza, Aliyu Muktar H
Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, Kano, Nigeria.
Department of Epidemiology and Population Health, University of Louisville, Louisville, Kentucky, USA.
Int Health. 2018 Sep 1;10(5):356-362. doi: 10.1093/inthealth/ihx074.
Cardiopulmonary disease is a major cause of morbidity and mortality in persons with sickle cell disease (SCD). Tricuspid regurgitant jet velocity (TRJV) and predicted forced expiratory volume in 1 s (FEV1%) predicted are independently associated with death in SCD. The goal of this study was to determine the prevalence of elevated TRJV and the association, if any, between TRJV and FEV1% predicted among persons with sickle cell anaemia (SCA) in Nigeria.
Using a cross-sectional design, we enrolled 100 adult Nigerians (≥15 y) with SCA. We screened participants using Doppler echocardiogram to determine their TRJV and assessed their lung function with spirometry.
The prevalence of elevated TRJV was 6%, with 74% of participants having low FEV1% predicted (<70%). TRJV was negatively correlated with FEV1%, but this finding was not statistically significant (Spearman's ρ=-0.0263, p=0.8058).
We found a low prevalence of elevated TRJV and a trend in association between TRJV and FEV1% predicted in Nigerian adults with SCA. Our findings underscore the need to explore further the relationship between SCD and cardiopulmonary disease in adults.
心肺疾病是镰状细胞病（SCD）患者发病和死亡的主要原因。三尖瓣反流喷射速度（TRJV）和预测的1秒用力呼气量（FEV1%预测值）与SCD患者的死亡独立相关。本研究的目的是确定尼日利亚镰状细胞贫血（SCA）患者中TRJV升高的患病率，以及TRJV与FEV1%预测值之间的关联（若有）。
采用横断面设计，我们纳入了100名成年尼日利亚人（≥15岁）SCA患者。我们使用多普勒超声心动图对参与者进行筛查以确定其TRJV，并通过肺量计评估其肺功能。
TRJV升高的患病率为6%，74%的参与者FEV1%预测值较低（<70%）。TRJV与FEV1%呈负相关，但这一发现无统计学意义（Spearman's ρ=-0.0263，p=0.8058）。
我们发现尼日利亚成年SCA患者中TRJV升高的患病率较低，且TRJV与FEV1%预测值之间存在关联趋势。我们的研究结果强调了进一步探索SCD与成年人心肺疾病之间关系的必要性。
