尼日利亚镰状细胞病成人患者三尖瓣反流喷射速度升高低于预期

Lower than expected elevated tricuspid regurgitant jet velocity in adults with sickle cell disease in Nigeria.

作者信息

Musa Baba Maiyaki, Odoh Chisom N, Galadanci Najibah A, Saidu Hadiza, Aliyu Muktar H

机构信息

Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, Kano, Nigeria.

Department of Epidemiology and Population Health, University of Louisville, Louisville, Kentucky, USA.

出版信息

Int Health. 2018 Sep 1;10(5):356-362. doi: 10.1093/inthealth/ihx074.

DOI:10.1093/inthealth/ihx074

PMID:29438485

Abstract

BACKGROUND

Cardiopulmonary disease is a major cause of morbidity and mortality in persons with sickle cell disease (SCD). Tricuspid regurgitant jet velocity (TRJV) and predicted forced expiratory volume in 1 s (FEV1%) predicted are independently associated with death in SCD. The goal of this study was to determine the prevalence of elevated TRJV and the association, if any, between TRJV and FEV1% predicted among persons with sickle cell anaemia (SCA) in Nigeria.

METHODS

Using a cross-sectional design, we enrolled 100 adult Nigerians (≥15 y) with SCA. We screened participants using Doppler echocardiogram to determine their TRJV and assessed their lung function with spirometry.

RESULTS

The prevalence of elevated TRJV was 6%, with 74% of participants having low FEV1% predicted (<70%). TRJV was negatively correlated with FEV1%, but this finding was not statistically significant (Spearman's ρ=-0.0263, p=0.8058).

CONCLUSIONS

We found a low prevalence of elevated TRJV and a trend in association between TRJV and FEV1% predicted in Nigerian adults with SCA. Our findings underscore the need to explore further the relationship between SCD and cardiopulmonary disease in adults.

摘要