Campiche R, Sandau P, Kurth E, Massironi M, Imfeld D, Schuetz R
DSM Nutritional Products, Personal Care & Aroma, Wurmisweg 576, CH-4303, Kaiseraugst, Switzerland.
IGV Institut für Getreideverarbeitung GmbH, Arthur Scheunert Allee 40-41, D-14558, Nuthetal, Germany.
Int J Cosmet Sci. 2018 Apr;40(2):187-192. doi: 10.1111/ics.12450. Epub 2018 Mar 14.
Skin ageing results from intrinsic but also extrinsic factors of which UV irradiation is a main cause. It is hence of interest to have means to protect skin from UV irradiation-induced damage. We selected an extract of the freshwater microalga Scenedesmus rubescens and assessed its potential to protect skin from photoageing caused by UV irradiation.
Skin cells in vitro and ex vivo were analysed for markers of UV irradiation-induced photodamage such as decreased viability, decreased collagen content, hyperpigmentation and sunburn cells.
We found that a dry extract of the microalga Scenedesmus rubescens was able to suppress cellular signs of ageing induced by UV irradiation. It enhanced dermal fibroblast viability, rescued dermal collagen content, inhibited the formation of sunburn cells and inhibited tyrosinase activity.
An extract of Scenedesmus rubescens showed broad activity against markers of UV irradiation-induced cutaneous ageing. It may therefore be used as a preventive or regenerative agent for anti-ageing strategies.
皮肤老化是由内在因素和外在因素共同导致的，其中紫外线照射是主要原因之一。因此，找到保护皮肤免受紫外线照射损伤的方法具有重要意义。我们选择了淡水微藻红球藻提取物，并评估了其保护皮肤免受紫外线照射引起的光老化的潜力。
对体外和离体皮肤细胞进行分析，检测紫外线照射引起的光损伤标志物，如活力下降、胶原蛋白含量降低、色素沉着和晒伤细胞。
我们发现红球藻的干燥提取物能够抑制紫外线照射引起的细胞衰老迹象。它提高了真皮成纤维细胞的活力，恢复了真皮胶原蛋白含量，抑制了晒伤细胞的形成，并抑制了酪氨酸酶的活性。
红球藻提取物对紫外线照射引起的皮肤老化标志物具有广泛的活性。因此，它可作为抗衰老策略的预防或再生剂。
