Yvonnet B, Coursaget P, Deubel V, Diop-Mar I, Digoutte J P, Chiron J P
J Med Virol. 1986 Aug;19(4):307-11. doi: 10.1002/jmv.1890190403.
In most developing countries, hepatitis B prevention is carried out early in life. In these countries, mobile immunization teams have a limited number of sessions to devote to each rural community; simultaneous administration of multiple antigens is thus normal practice. We compared the immune responses of Senegalese children to the separate or simultaneous injections of yellow fever and hepatitis B vaccines. Injections were given at the time of booster injection for hepatitis B vaccine. Yellow fever antibodies were detected in similar proportions in infants immunized with either yellow fever vaccine alone or yellow fever and hepatitis B vaccines simultaneously. However, a lower proportion of high yellow fever antibody levels were observed when the two vaccines were injected simultaneously. No reduction in the anamnestic response of antibodies against the surface antigen of hepatitis B virus (anti-HBs) was observed when yellow fever vaccine was injected at the same time as the booster dose of hepatitis B vaccine. Since no untoward reactions were noted, it is concluded that hepatitis B and yellow fever vaccines can be administered at the same time.
在大多数发展中国家，乙肝预防工作在儿童早期开展。在这些国家，流动免疫团队分配给每个农村社区的接种场次有限；因此，同时接种多种抗原是常规做法。我们比较了塞内加尔儿童对单独接种或同时接种黄热病疫苗和乙肝疫苗的免疫反应。接种在乙肝疫苗加强针接种时进行。单独接种黄热病疫苗或同时接种黄热病疫苗和乙肝疫苗的婴儿中，检测到黄热病抗体的比例相似。然而，同时接种两种疫苗时，观察到高黄热病抗体水平的比例较低。当黄热病疫苗与乙肝疫苗加强针同时接种时，未观察到乙肝病毒表面抗原抗体（抗-HBs）回忆反应的降低。由于未发现不良反应，得出结论：乙肝疫苗和黄热病疫苗可以同时接种。
