Coursaget P, Fritzell B, Blondeau C, Saliou P, Diop-Mar I
Institut de Virologie de Tours, Faculté de Pharmacie, Tours, France.
Vaccine. 1995 Jan;13(1):109-11. doi: 10.1016/0264-410x(95)80020-e.
Previous studies have shown an absence of interaction between hepatitis B (HB) vaccine and other vaccines used in EPI programmes except for an apparent decrease of yellow fever antibody levels when hepatitis B and yellow fever vaccines are given simultaneously. We have therefore reinvestigated the interaction of these two vaccines and assessed the absence of interaction between inactivated polio vaccine and recombinant or plasma-derived HB vaccine. The immune responses to polio vaccine injected simultaneously with plasma-derived or recombinant HB vaccine were observed to be equivalent and similar to those observed in the literature. In this randomized study, the immune responses to yellow fever injected simultaneously with plasma-derived or recombinant HB vaccine were comparable to those observed after separate administration of each vaccine. Moreover, no increase in adverse reactions was noted.
以往的研究表明，除了乙肝疫苗和黄热病疫苗同时接种时黄热病抗体水平明显下降外，乙肝疫苗与扩大免疫规划中使用的其他疫苗之间不存在相互作用。因此，我们重新研究了这两种疫苗的相互作用，并评估了灭活脊髓灰质炎疫苗与重组乙肝疫苗或血浆源性乙肝疫苗之间不存在相互作用的情况。观察到与血浆源性或重组乙肝疫苗同时接种的脊髓灰质炎疫苗的免疫反应与文献中观察到的相当且相似。在这项随机研究中，与血浆源性或重组乙肝疫苗同时接种的黄热病疫苗的免疫反应与分别接种每种疫苗后观察到的相当。此外，未发现不良反应增加。
