1st Department of Neurology, Aeginition Hospital, Faculty of Medicine, National Kapodistrian University of Athens, Vas. Sofias Ave. 72-74, GR-11528 Athens, Greece; Department of Neurology, Army Share Fund Hospital (NIMTS), Monis Petraki 10-12, GR-11521 Athens, Greece.
1st Department of Neurology, Aeginition Hospital, Faculty of Medicine, National Kapodistrian University of Athens, Vas. Sofias Ave. 72-74, GR-11528 Athens, Greece.
Mult Scler Relat Disord. 2018 Apr;21:1-8. doi: 10.1016/j.msard.2018.02.003. Epub 2018 Feb 6.
Cognitive impairment (CI) has been associated with numerous magnetic resonance imaging (MRI) indices in multiple sclerosis (MS) patients. In this study we investigated the association of a large set of 2D and 3D MRI markers with cognitive function in MS.
A sample of 61 RRMS patients (mean age 41.8 ± 10.6 years old, 44 women, mean disease duration 137.9 ± 83.9 months) along with 51 age and gender matched healthy controls was used in this cross-sectional study. Neuropsychological and other tests, along with a large set of 2D/3D MRI evaluations were made.
44.3% of patients had CI. CI patients had more disability, physical fatigue than non-CI patients and more psychological distress than non-CI patients and HCs. Also, CI patients had significantly larger third ventricle width and volume, smaller coprus callosum index and larger lesion volume than non-CI patients. These MRI markers also significantly predicted cognitive scores after adjusting for age and education, explaining about 30.6% of the variance of the total cognitive score.
Selected linear and volumetric MRI indices predict cognitive function in MS. Future studies should expand these results by exploring longitudinal changes and producing normative data.
认知障碍（CI）与多发性硬化症（MS）患者的许多磁共振成像（MRI）指标有关。在这项研究中，我们研究了大量 2D 和 3D MRI 标志物与 MS 认知功能的相关性。
本横断面研究纳入了 61 例 RRMS 患者（平均年龄 41.8 ± 10.6 岁，44 名女性，平均病程 137.9 ± 83.9 个月）和 51 名年龄和性别匹配的健康对照者。对其进行神经心理学和其他测试，以及大量 2D/3D MRI 评估。
44.3%的患者存在 CI。与非 CI 患者相比，CI 患者的残疾程度更高、体力疲劳更严重，且心理困扰比非 CI 患者和健康对照者更严重。此外，CI 患者的第三脑室宽度和体积明显更大，胼胝体指数更小，病灶体积更大。这些 MRI 标志物在调整年龄和教育因素后，仍然与认知评分显著相关，可解释总认知评分约 30.6%的差异。
选定的线性和体积 MRI 指标可预测 MS 的认知功能。未来的研究应通过探索纵向变化并生成正常数据来扩展这些结果。
