Guenter Wojciech, Betscher Ewa, Bonek Robert
Department of Clinical Neuropsychology, Nicolaus Copernicus University, 87-100 Toruń, Poland, and Collegium Medicum, 85-094 Bydgoszcz, Poland.
Division of Neurology and Clinical Neuroimmunology, Regional Specialized Hospital in Grudziądz, 86-300 Grudziądz, Poland.
J Clin Med. 2022 May 18;11(10):2841. doi: 10.3390/jcm11102841.
The third ventricle width (3VW) is an easily calculated measure of brain atrophy. The aim of this study was to evaluate the relation of 3VW to cognitive impairment with adjustment for demographic and clinical confounders, including depression, anxiety, and fatigue, as well as to disability in patients with multiple sclerosis (MS). Symbol Digit Modalities Test, California Verbal Learning Test, Brief Visuospatial Memory Test-Revised, Expanded Disability Status Scale (EDSS), Hospital Anxiety and Depression Scale, and Modified Fatigue Impact Scale (MFIS) were analysed in 93 patients with MS. Neuropsychological performance was compared to that of 150 healthy controls. Axial images from 3D FLAIR were used to measure 3VW. In total, 25% of MS patients were impaired in at least two neuropsychological tests. Cognitive impairment and EDSS were associated with 3VW. Age and 3VW were the strongest predictors of cognitive impairment. The multiple regression model including age, 3VW, education, EDSS, and MFIS explained 63% of the variance of neuropsychological tests results, whereas 3VW, age and duration of the disease were significant predictors of EDSS. This study confirms the predictive value of 3VW for neurological status of patients with MS, especially for cognitive impairment after adjustment for demographic and clinical confounders.
第三脑室宽度（3VW）是一种易于计算的脑萎缩测量指标。本研究的目的是评估在对人口统计学和临床混杂因素（包括抑郁、焦虑和疲劳）进行校正的情况下，3VW与认知障碍的关系，以及与多发性硬化症（MS）患者残疾的关系。对93例MS患者进行了符号数字模式测验、加利福尼亚言语学习测验、简短视觉空间记忆测验修订版、扩展残疾状态量表（EDSS）、医院焦虑抑郁量表和改良疲劳影响量表（MFIS）的分析。将神经心理学表现与150名健康对照者进行比较。使用3D FLAIR的轴位图像测量3VW。总共有25%的MS患者在至少两项神经心理学测试中受损。认知障碍和EDSS与3VW相关。年龄和3VW是认知障碍的最强预测因素。包含年龄、3VW、教育程度、EDSS和MFIS的多元回归模型解释了神经心理学测试结果方差的63%，而3VW、年龄和病程是EDSS的显著预测因素。本研究证实了3VW对MS患者神经状态的预测价值，尤其是在对人口统计学和临床混杂因素进行校正后对认知障碍的预测价值。
